Synthesis and characterization of a pegylated derivative of 3-(1,2,3,6-tetrahydro-pyridin-4yl)-1H-indole (IDT199): A high affinity SERT ligand for conjugation to quantum dots
Synthesis and characterization of a pegylated derivative of 3-(1,2,3,6-tetrahydro-pyridin-4yl)-1H-indole (IDT199): A high affinity SERT ligand for conjugation to quantum dots
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DOI：
10.1016/j.bmcl.2007.07.061
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发表时间：
2007-10-15
影响因子：
2.7
通讯作者：
Rosenthal, Sandra J.
中科院分区：
文献类型：
--
作者：
Tomlinson, Ian D.;Warnerment, Michael R.;Rosenthal, Sandra J.
由封装在掺镉硫化锌壳中的硒化镉核组成的量子点具有彻底改变活细胞培养物的荧光成像的潜力。为了利用这些荧光探针，有必要用生物活性配体将它们功能化。在本文中，我们报告的设计和合成的配体，具有高亲和力的5-羟色胺转运蛋白（SERT），可以共轭量子点。(c)2007爱思唯尔有限公司保留所有权利。
Quantum dots consisting of a cadmium selenide core encapsulated in a shell of cadmium doped zinc sulfide have the potential to revolutionize fluorescent imaging of live cell cultures. In order to utilize these fluorescent probes it is necessary to functionalize them with biologically active ligands. In this paper we report the design and synthesis of a ligand that has a high affinity for the serotonin transporter (SERT) that may be conjugated to quantum dots. (c) 2007 Elsevier Ltd. All rights reserved.