Strengthening sleep-autonomic interaction via acoustic enhancement of slow oscillations
Strengthening sleep-autonomic interaction via acoustic enhancement of slow oscillations
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DOI：
10.1093/sleep/zsz036
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发表时间：
2019-05-01
期刊：
影响因子：
5.6
通讯作者：
Zee, Phyllis C.
中科院分区：
文献类型：
--
作者：
Grimaldi, Daniela;Papalambros, Nelly A.;Zee, Phyllis C.
慢波睡眠（SWS）对整体健康很重要，因为它影响许多生理过程，包括心脏代谢功能。睡眠和自主神经系统（ANS）活动在解剖学和生理学水平上密切相关。睡眠相关的自主神经功能变化可能是SWS影响体内许多系统的主要途径。在不同的睡眠阶段，ANS活动有特征性的变化。值得注意的是，在非快速眼动睡眠中，进入SWS的进展的特征是副交感神经活动增加，这是心血管健康的重要指标。增强慢波活动（SWA，0.5-4 Hz）的实验操作可以改善睡眠介导的记忆和免疫功能。然而，SWA增强对自主调节的影响尚未研究。在这里，我们采用了一种自适应算法，以提供50毫秒的声音相位锁定到慢波，定期暂停刺激（5秒开/5秒关），在健康的年轻人。我们试图确定声增强SWA是否改变副交感神经活动在SWS评估与心率变异性（HRV），和晚上到早上的变化，心率变异性，血浆皮质醇和血压。与假手术条件相比，刺激增加了ON与OFF间期的SWA。这种ON/OFF SWA增强与皮质醇水平和交感神经活动指数的夜间至早晨变化的减少有关。此外，在睡眠周期2-3的ON间期中SWA的增强伴随着副交感神经活动（高频，HRV）的增加。总之，这些研究结果表明，声增强SWA在睡眠中的自主神经功能有积极的影响。加强睡眠期间大脑与心脏相互作用的方法可能对心血管健康有重要意义。
Slow-wave sleep (SWS) is important for overall health since it affects many physiological processes including cardio-metabolic function. Sleep and autonomic nervous system (ANS) activity are closely coupled at anatomical and physiological levels. Sleep-related changes in autonomic function are likely the main pathway through which SWS affects many systems within the body. There are characteristic changes in ANS activity across sleep stages. Notably, in non-rapid eye-movement sleep, the progression into SWS is characterized by increased parasympathetic activity, an important measure of cardiovascular health. Experimental manipulations that enhance slow-wave activity (SWA, 0.5-4 Hz) can improve sleep-mediated memory and immune function. However, effects of SWA enhancement on autonomic regulation have not been investigated. Here, we employed an adaptive algorithm to deliver 50 ms sounds phase-locked to slow-waves, with regular pauses in stimulation (5 s ON/5 s OFF), in healthy young adults. We sought to determine whether acoustic enhancement of SWA altered parasympathetic activity during SWS assessed with heart rate variability (HRV), and evening-to-morning changes in HRV, plasma cortisol, and blood pressure. Stimulation, compared with a sham condition, increased SWA during ON versus OFF intervals. This ON/OFF SWA enhancement was associated with a reduction in evening-to-morning change of cortisol levels and indices of sympathetic activity. Furthermore, the enhancement of SWA in ON intervals during sleep cycles 2-3 was accompanied by an increase in parasympathetic activity (high-frequency, HRV). Together these findings suggest that acoustic enhancement of SWA has a positive effect on autonomic function in sleep. Approaches to strengthen brain-heart interaction during sleep could have important implications for cardiovascular health.