Immunotoxicity of aluminum
Immunotoxicity of aluminum
复制标题
铝的免疫毒性
DOI：
10.1016/j.chemosphere.2013.10.052
复制
发表时间：
2014
期刊：
影响因子：
8.8
通讯作者：
Li Haitao
中科院分区：
文献类型：
--
作者：
Zhu Yanzhu;Li Yanfei;Miao Liguang;Wang Yingping;Liu Yanhuan;Yan Xijun;Cui Xuezhe;Li Haitao
铝存在于所有人类的日常生活中。近年来，随着铝污染发生率的增加，铝对免疫功能的毒性越来越引起人们的关注。即使受到越来越多的关注，铝免疫毒性的机制仍然不清楚。本文综述了铝对小鼠免疫毒性的作用机制，包括铝对小鼠脾组织中微量元素、α-醋酸酯酶(ANAE)细胞、细胞因子、补体、免疫球蛋白以及巨噬细胞的影响。文献研究表明，铝可降低脾组织铁(Fe)和锌(Zn)水平，但铝对脾组织铜(Cu)水平的影响尚不明确，且存在争议。铝暴露可抑制ANAE+细胞水平、IL-2的产生和巨噬细胞的功能。在其他关键细胞因子方面，研究表明，铝在体外抑制肿瘤坏死因子-α的产生，而在体内对肿瘤坏死因子-α的形成的影响不明显。铝暴露降低补体3(C3)水平，但对补体4(C4)水平的影响不明显。铝暴露对免疫球蛋白、免疫球蛋白M和免疫球蛋白A水平的影响是相互矛盾的。综上所述，文献中的几项研究结果表明，铝可以对免疫功能产生不利影响。
Aluminum (Al) is present in the daily life of all humans. With the incidence of Al contamination increased in recent years, the toxicity of Al on the immune function has attracted more attention. Even with this increased attention, the mechanism of Al immunotoxicity still remains unclear. The mechanism of Al immunotoxicity reviewed herein focused on the effects of Al on the splenic trace elements, the status of α-naphthyl acetate esterase (ANAE) cells, cytokines, complement and immunoglobulins, as well as macrophages. The studies in the literature showed that Al decreased splenic iron (Fe) and zinc (Zn) levels, but the effects of Al on splenic copper (Cu) level was ambiguous and controversial. Al exposure inhibited levels of ANAE+cells, the production of interleukin (IL)-2 and the functions of macrophages. With respect to other key cytokines, studies showed that Al suppressed the production of tumor necrosis factor (TNF)-αin vitro; effects of Al on TNF-α formationin vivowere less overt. Al exposure reduced complement 3 (C3) level, but effects of Al exposure on complement 4 (C4) level were not as clear-cut. Lastly, the effects of Al exposure on the IgG, IgM and IgA levels were conflicting. Taken in totality, the results of several studies in the literature demonstrated that Al could impart adverse effects on immune function.