Eleven patients with primary thyroid lymphoma: a single center experience
Eleven patients with primary thyroid lymphoma: a single center experience
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DOI：
10.3906/sag-1611-91
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发表时间：
2017-01-01
影响因子：
2.3
通讯作者：
Akin, Murat
中科院分区：
文献类型：
--
作者：
Bostanci, Hasan;Dikmen, Kursat;Akin, Murat
原发性甲状腺淋巴瘤（PTL）是一种非常罕见的甲状腺恶性肿瘤。应及时准确地诊断和治疗。我们的目的是评估PTL患者的诊断方法和治疗结果。材料和方法：我们回顾性分析了2009年至2015年在我院诊断的11例PTL患者的记录。年龄，性别，阶段，组织病理学类型，桥本甲状腺炎的存在，诊断方法，治疗类型，和复发进行了检查。结果：6例患者是女性，5例男性，和患者的中位年龄为61岁（范围：15-76岁）。所有患者的颈部都有一个大的可触及的肿块。所有患者均行细针穿刺（FNA）活检，但仅对7例患者的诊断有用。4例患者行切除和手术活检。所有患者均为非霍奇金B细胞淋巴瘤，其中弥漫性大B细胞淋巴瘤（DLBCL）9例，粘膜相关淋巴组织（MALT）淋巴瘤2例。在1例患者中观察到复发。中位生存期为34个月。结论：PTL的诊断首选FNA活检，治疗应根据疾病是否局限于甲状腺，其组织学类型，其阶段。
Background/aim: Primary thyroid lymphoma (PTL) is a very rare thyroid malignancy. It should be diagnosed and treated immediately and accurately. Our aim was to evaluate the diagnostic methods and treatment results for patients with PTL.Materials and methods: We retrospectively evaluated the records of 11 patients with PTL from 2009 to 2015, diagnosed at our institute. Age, sex, stage, histopathologic type, presence of Hashimoto's thyroiditis, diagnostic methods, treatment types, and recurrence were examined.Results: Six patients were female, 5 were male, and the median age of the patients was 61 years (range: 15-76 years). All patients had a large palpable mass in the neck. Fine needle aspirate (FNA) biopsy was performed in all patients; however, it was useful only in the diagnosis of 7 patients. Excisional and surgical biopsy was performed in 4 patients. All patients had non-Hodgkin B-cell lymphoma, including 9 cases of diffuse large B-cell lymphoma (DLBCL), and 2 patients had mucosa-associated lymphoid tissue (MALT) lymphoma. Recurrence was observed in one patient. Median survival was 34 months.Conclusions: The preferred option for the diagnosis of PTL should be FNA biopsy, and the treatment should be decided on according to whether the disease is limited to the thyroid gland or not, its histological type, and its stage.