Development of tolerance to the disruptive effects of cocaine on repeated acquisition and performance of response sequences.
Development of tolerance to the disruptive effects of cocaine on repeated acquisition and performance of response sequences.
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对可卡因对重复获取和执行反应序列的破坏性影响产生耐受性。
DOI：
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发表时间：
1977
影响因子：
3.5
通讯作者：
D. M. Thompson
中科院分区：
文献类型：
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作者：
D. M. Thompson
小猪通过对三个键按特定顺序做出四个反应来获得食物。错误会产生5秒的超时时间，在此期间，按键灯关闭，响应无效。为了建立一个重复采集的基线，正确反应的顺序从一个会话到另一个会话。可卡因（3 mg/kg）扰乱了行为：总错误增加，持续错误的相对频率增加，会话内错误减少率（学习）下降，总尝试时间（暂停）增加。在重复给药期间（30-50次），这些作用消失，即，宽容发展。耐受性没有发展，但是，可卡因诱导的超时反应的增加或减少，这种影响是非破坏性的意义上说，他们没有减少食物强化率。为了进行比较，还在“表现”条件下研究了可卡因（3-10 mg/kg），其中正确反应的顺序从一个会话到另一个会话是相同的。认知行为增加了操作错误和停顿，但在学习条件下，耐受性发展得更快。耐受性的快速发展可能是由于在表演条件下，对行为的刺激控制更强。
Pigeons obtained food by making four responses on three keys in a specified sequence. Errors produced 5-second timeout periods, during which the keylights were off and responses had no effect. To establish a base line of repeated acquisition, the sequence of correct responses was changed from session to session. Cocaine (3 mg/kg) disrupted the behavior: total errors increased, the relative frequency of perseverative errors increased, the rate of within-session error reduction (learning) decreased and the total trial time (pausing) increased. During repeated drug administration (30-50 sessions), these effects disappeared, i.e., tolerance developed. Tolerance did not develop, however, to cocaine-induced increases or decreases in timeout responding; such effects were nondisruptive in the sense thay they did not reduce the rate of food reinforcement. For comparison, cocaine (3-10 mg/kg) was also studied under a "performance" condition, in which the sequence of correct responses was the same from session to session. Cocaine increased performance errors and produced pausing, but tolerance developed more quickly under the learning condition . The more rapid development of tolerance was presumably due to the stronger stimulus control of behavior under the performance condition.