PERIPHERAL-NERVES IN EARLY EXPERIMENTAL DIABETES - EXPANSION OF ENDONEURIAL SPACE AS A CAUSE OF INCREASED WATER-CONTENT
PERIPHERAL-NERVES IN EARLY EXPERIMENTAL DIABETES - EXPANSION OF ENDONEURIAL SPACE AS A CAUSE OF INCREASED WATER-CONTENT
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DOI：
10.1007/bf01263449
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发表时间：
1978-01-01
期刊：
影响因子：
8.2
通讯作者：
JAKOBSEN, J
中科院分区：
文献类型：
--
作者：
JAKOBSEN, J
是否神经水含量和雪旺细胞胞质增加，在早期实验性糖尿病，建议在山梨醇理论，进行了检查。链脲佐菌素糖尿病大鼠坐骨神经湿重增加。雪旺细胞胞质减少30%。增加的湿重是由神经的横截面积的扩大，这是由神经内膜空间的扩张解释。研究结果表明存在神经内膜水肿，部分与山梨醇理论相冲突。神经纤维周围空间的扩展可以解释糖尿病患者对缺血的抵抗力增加。
Whether the nerve water content and the Schwann cell cytoplasm are increased in early experimental diabetes, as suggested in the sorbitol theory, was examined. The sciatic nerves of streptozotocin diabetic rats had an increased wet weight. The amount of Schwann cell cytoplasm was reduced by 30%. The increased wet weight was paralleled by enlargement of the cross sectional area of the nerve which was explained by an expansion of the endoneurial space. The findings indicate the existence of endoneurial edema and are in part in conflict with the sorbitol theory. Extension of the space surrounding the nerve fibers may explain the increased resistance to ischemia in diabetic patients.