The Intestinal Tumour Microenvironment
The Intestinal Tumour Microenvironment
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DOI：
10.1007/978-3-030-36214-0_1
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Kemp, R. A.
中科院分区：
文献类型：
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作者：
Leman, J. K. H.;Munoz-Erazo, L.;Kemp, R. A.
肠道肿瘤的肿瘤微环境（TME）是高度复杂的，包括基质细胞、肿瘤细胞、免疫细胞和成纤维细胞以及微生物的网络。肿瘤位置、环境因素和肿瘤细胞本身影响TME内的细胞。免疫细胞可以破坏肿瘤细胞，并与更好的患者预后和对治疗的反应有关;然而，免疫细胞具有高度可塑性，容易受到影响，从而促进肿瘤生长。局部免疫细胞和微生物组之间的相互作用可导致肠道肿瘤的进展或消退。在本章中，我们将讨论肿瘤的发展和进展如何影响周围的微环境，并受其影响，重点关注免疫和成纤维细胞以及肠道微生物群，特别是在结直肠癌的背景下。
The tumour microenvironment (TME) of intestinal tumours is highly complex and comprises a network of stromal cells, tumour cells, immune cells and fibroblasts, as well as microorganisms. The tumour location, environmental factors and the tumour cells themselves influence the cells within the TME. Immune cells can destroy tumour cells and are associated with better patient prognosis and response to therapy; however, immune cells are highly plastic and easily influenced to instead promote tumour growth. The interaction between local immune cells and the microbiome can lead to progression or regression of intestinal tumours. In this chapter, we will discuss how tumour development and progression can influence, and be influenced by, the microenvironment surrounding it, focusing on immune and fibroblastic cells, and the intestinal microbiota, particularly in the context of colorectal cancer.