Regulation of osteoclast function
Regulation of osteoclast function
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DOI：
10.3109/s10165-011-0530-8
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发表时间：
2012-04
影响因子：
2.2
通讯作者：
I. Nakamura;N. Takahashi;E. Jimi;N. Udagawa;T. Suda
中科院分区：
文献类型：
--
作者：
I. Nakamura;N. Takahashi;E. Jimi;N. Udagawa;T. Suda
破骨细胞是终末分化的多核细胞，是骨的主要吸收细胞，在骨骼的形成和质量的调节中起核心作用。破骨细胞的分化和功能的分子机制长期以来一直不清楚。在过去的二十年里，已经开发并采用了一些新的方法来研究破骨细胞生物学。本文就近年来破骨细胞活化和功能的分子机制的研究进展作一综述。
Osteoclasts are terminally differentiated multinucleated cells that are the principal resorptive cells of bone, playing a central role in the formation of the skeleton and regulation of its mass. The molecular events involved in the differentiation and function of osteoclasts had not been clarified for a long time. Over the past two decades, several novel approaches have been developed and adopted to investigate osteoclast biology. In the present review, we would like to update recent progress in the elucidation of the molecular mechanism of osteoclast activation and function.