Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses.
Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses.
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DOI：
10.1007/s00281-015-0477-5
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发表时间：
2015-05
影响因子：
9
通讯作者：
Badovinac, Vladimir P.
中科院分区：
文献类型：
--
作者：
Khan, Shaniya H.;Badovinac, Vladimir P.
记忆性CD8 T细胞通过在再次感染后协调病原体感染细胞的快速消除，在为免疫宿主提供保护方面发挥关键作用。单核增生李斯特菌的系统性细菌感染一直是研究人员表征病原体特异性CD8 T细胞反应的首选方法，而对单核增生李斯特菌生物学的深入了解提供了宝贵的实验工具，用于增加我们对记忆性CD8 T细胞分化的理解。在这里，我们描述了如何利用这种小鼠感染模型系统的工具来表征近交和遗传多样性的远交宿主中病原体特异性CD8 T细胞，因为它们在体内经历naïve-to-memory CD8 T细胞分化。我们还讨论了研究单核细胞增生乳杆菌诱发的CD8 T细胞反应如何为败血症和肥胖等临床相关疾病中T细胞免疫减弱的程度提供了见解。总的来说，这篇综述将强调细胞内病原菌单核增生乳杆菌的感染如何使系统CD8 T细胞反应分析成为可能，并极大地促进了记忆性CD8 T细胞的产生和分化。
Memory CD8 T cells play a critical role in providing protection to immune hosts by orchestrating rapid elimination of pathogen-infected cells after re-infection. Systemic bacterial infection with Listeria monocytogenes has been a favored approach for researchers to characterize pathogen-specific CD8 T cell responses, and in-depth understanding of L. monocytogenes biology has provided invaluable experimental tools that have been used to increase our understanding of memory CD8 T cell differentiation. Here, we describe how the tools from this murine model system of infection have been utilized to characterize pathogen-specific CD8 T cells in inbred and genetically diverse outbred hosts as they undergo naïve-to-memory CD8 T cell differentiation in vivo. We also discuss how studying L. monocytogenes-evoked CD8 T cell responses have provided insight on the degree of diminished T cell immunity in clinically relevant conditions such as sepsis and obesity. Overall, this review will highlight how infection with the intracellular pathogen L. monocytogenes has enabled analysis of systemic CD8 T cell responses and greatly contributed to what is known about memory CD8 T cell generation and differentiation.
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DOI：
10.1084/jem.20031051
发表时间：
2003-11-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Berg RE;Crossley E;Murray S;Forman J
通讯作者：
Forman J
影响因子：
7
作者：
Curtsinger JM;Mescher MF
通讯作者：
Mescher MF
DOI：
10.1084/jem.20001021
发表时间：
2002-03-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Blattman JN;Antia R;Sourdive DJ;Wang X;Kaech SM;Murali-Krishna K;Altman JD;Ahmed R
通讯作者：
Ahmed R
DOI：
10.1084/jem.175.6.1531
发表时间：
1992-06-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Harty JT;Bevan MJ
通讯作者：
Bevan MJ
影响因子：
64.8
作者：
BIELECKI, J;YOUNGMAN, P;PORTNOY, DA
通讯作者：
PORTNOY, DA