Perspectives on the basic reproductive ratio
Perspectives on the basic reproductive ratio
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DOI：
10.1098/rsif.2005.0042
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发表时间：
2005-09-22
影响因子：
3.9
通讯作者：
Wahl, LM
中科院分区：
文献类型：
--
作者：
Heffernan, JM;Smith, RJ;Wahl, LM
基本生殖比，R-0，定义为在易感人群中，单个个体在其整个感染期内所产生的继发感染的预期数量。这一概念是流行病学和宿主内病原体动力学研究的基础。最重要的是，R-0通常作为预测感染是否会扩散的阈值参数。然而，共享这种阈值行为的相关参数可能会或可能不会给出R-0的真实值。在本文中，我们给出了一个简短的概述，制定R-0和替代阈值参数的确定性，非结构化模型的常用方法。我们还回顾了流行病学数据中估计R-0的常用方法。最后，我们调查了最近使用的R-0评估新出现的疾病，如严重急性呼吸系统综合征和禽流感，一些最近的牲畜疾病，和病媒传播的疾病疟疾。登革热和西尼罗河病毒。
The basic reproductive ratio, R-0, is defined as the expected number of secondary infections arising from a single individual during his or her entire infections period, in a population of susceptibles. This concept is fundamental to the study of epidemiology and within-host pathogen dynamics. Most importantly, R-0 often serves as a threshold parameter that predicts whether an infection will spread. Related parameters which share this threshold behaviour, however, may or may not give the true value of R-0. In this paper we give a brief overview of common methods of formulating R-0 and surrogate threshold parameters from deterministic, non-structured models. We also review common means of estimating R-0 from epidemiological data. Finally, we survey the recent use of R-0 in assessing emerging diseases, such as severe acute respiratory syndrome and avian influenza, a number of recent livestock diseases, and vector-borne diseases malaria. dengue and West Nile virus.