Gene therapy for the treatment of heart failure--calcium signaling.
Gene therapy for the treatment of heart failure--calcium signaling.
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DOI：
10.1016/s1043-0679(03)70006-9
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发表时间：
2003-07-01
影响因子：
2.5
通讯作者：
Hajjar, Roger J
中科院分区：
文献类型：
--
作者：
Bernecker, Oliver Y;del Monte, Federica;Hajjar, Roger J
在过去的十年中，对心功能不全的分子机制的认识急剧增加，并为心力衰竭的新治疗选择带来了相当大的潜力。细胞内钙信号的改变在心力衰竭的病理生理学中起着至关重要的作用，近年来，体细胞基因转移已被确定为帮助理解特定钙处理蛋白在心力衰竭中的相对贡献的重要工具。本文综述了基因递送技术的最新进展，旨在全球心肌转染，并讨论了分子治疗靶点内的细胞内钙信号通路在心力衰竭。
The knowledge of molecular mechanisms indicated in cardiac dysfunction has increased dramatically over the last decade and yields considerable potential for new treatment options in heart failure. Alterations in intracellular calcium signaling play a crucial role in the pathophysiology of heart failure, and in recent years, somatic gene transfer has been identified as an important tool to help understand the relative contribution of specific calcium-handling proteins in heart failure. This article reviews recent advances in gene delivery techniques aimed at global myocardial transfection and discusses molecular therapeutic targets identified within intracellular calcium signaling pathways in heart failure.