Noncondylomatous Cervical Wart Virus Infection
Noncondylomatous Cervical Wart Virus Infection
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非湿疣性宫颈疣病毒感染
作者：
R. Reid;C. Laverty;M. Coppleson;W. Isarangkul;E. Hills
人类乳头瘤病毒(HPV)感染生殖道经常累及宫颈上皮，并产生一种肉眼可见的扁平病变，作者将其称为非尖锐湿疣宫颈疣病毒感染(NCWVI)。在6个月的时间里，7281例常规宫颈涂片中的92例(1.3%)和183例镜下穿孔活检中的46例(25%)显示了疣病毒感染的形态证据。电子显微镜检查53例患者中有24例(45%)证实了HPV的病原学作用。NCWVI的镜特征主要为上皮混浊和血管异型性，常与宫颈上皮内瘤变相混淆。表面轮廓、颜色、血管图案和地形的不同通常允许镜下的区分。这两种情况有时并存；这种联系是因果关系还是偶然关系目前尚不清楚。
Human papillomavirus (HPV) infections of the genital tract frequently involve cervical epithelium and produce a macroscopically flat lesion that the authors have called noncondylomatous cervical wart virus infection (NCWVI). Over a 6-month period, 92 of 7281 routine cervical smears (1.3%) and 46 of 183 colposcopically directed punch biopsies (25%) showed morphologic evidence of wart virus infection. The etiologic role of HPV was confirmed by the demonstration of virus particles in 24 of 53 cases (45%) examined by electron microscopy. The colposcopic features of NCWVI consist principally of epithelial opacity and vascular atypia, leading to frequent confusion with cervical intraepithelial neoplasia. Differences in surface contour, color, vascular patterns, and topography generally permit colposcopic differentiation. These 2 conditions sometimes coexist; whether the association is causal or casual is not presently known.