Depression promotes lung carcinoma progression by regulating the tumor microenvironment in tumor-bearing models of C57BL/6J mice
Depression promotes lung carcinoma progression by regulating the tumor microenvironment in tumor-bearing models of C57BL/6J mice
复制标题
抑郁症通过调节C57BL/6J小鼠荷瘤模型中的肿瘤微环境促进肺癌进展
DOI：
10.1016/j.neulet.2021.135851
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发表时间：
2021-04-16
影响因子：
2.5
通讯作者：
Zhang, Rong
中科院分区：
文献类型：
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作者：
Cui, Sainan;Lin, Huiyuan;Zhang, Rong
心理应激是肺癌患者的常见病因，并作为预后不良和晚期癌症临床分期的潜在指标。有证据表明，抑郁与肺癌的进展呈正相关。然而，精神障碍对肺癌影响的机制尚未得到大量和系统的探讨。我们推测精神障碍可能影响肿瘤微环境和免疫细胞的调节。我们采用慢性不可预见温和应激（C57 BL/6 J）方法诱导小鼠抑郁模型，建立C57 BL/6 J小鼠荷瘤模型。结果显示，在CASES+肿瘤组中，肺癌的恶化明显加速。值得注意的是，PD-L1在肿瘤组织中的表达在肿瘤微环境中增加，伴随着CD 8水平的下降。根据肿瘤迁移的日期，我们的结果表明，MMPs和VEGF显着增加后，CIMPS+肿瘤治疗。因此，我们证明了肿瘤微环境的调节对于抑郁症促进的肺癌迁移至关重要。
Psychological stress is a common etiology among patients with lung cancer and serves as a potential indication of poor prognosis and advanced cancer clinical stage. Evidence indicates that depression is positively correlated with the evolvement of lung carcinoma. Nevertheless, the mechanisms underlying the effects of mental disorder on lung cancer have not been considerably and systemically explored. We hypothesized that mental disorder may affect the adjustment of the tumor microenvironment and immune cells. We used the chronic unpredictable mild stress (CUMS) procedure to induce depressed mice models and established tumor-bearing models of C57BL/6 J mice. Results revealed that the worsening of lung cancer was notably hastened in the CUMS + tumor group. Notably, the expression of PD-L1 in tumor issues increased in the tumor microenvironment, accompanied with a decline in the levels of CD8. On the basis of the date of tumor migration, our results indicated that MMPs and VEGF significantly increased after CUMS + tumor treatment. Thus, we demonstrated that modulation of the tumor microenvironment is pivotal for depression-promoted lung cancer migration.