Rates of coinfection with other respiratory pathogens in patients positive for coronavirus disease 2019 (COVID-19)
Rates of coinfection with other respiratory pathogens in patients positive for coronavirus disease 2019 (COVID-19)
复制标题
DOI：
10.1002/emp2.12172
复制
发表时间：
2020-08-01
影响因子：
2.3
通讯作者：
Tomaszewski, Christian A.
中科院分区：
文献类型：
--
作者：
Castillo, Edward M.;Coyne, Christopher J.;Tomaszewski, Christian A.
本研究的目的是评估2019年新冠肺炎与其他呼吸道感染的重叠感染率。方法对2020年3月10日至2020年3月23日期间2所医院学术医学中心和2所急救中心的SARS-CoV-2检测数据进行回顾性分析。根据美国疾病控制和预防中心的指导方针，测试针对的是高危患者。人口统计数据包括年龄组和性别。实验室检测结果包括SARS-CoV-2、快速甲型/乙型流感和上呼吸道病原体核酸检测。结果接受SARS冠状病毒检测的471名急诊科患者和117名紧急护理中心患者在前两周获得了完整的实验室结果。共有51名患者(8.7%)新冠肺炎检测呈阳性，其中只有1名患者的另一种呼吸道感染检测也呈阳性。1例新冠肺炎阳性患者同时检出甲型流感病毒。在5 37例新冠肺炎检测阴性的患者中，有33例(6.1%)上呼吸道病原体核酸检测试验呈阳性。结论本研究调查了5 1例新冠肺炎阳性患者中的混合感染，1例同时检出甲型流感。
ObjectivesThe purpose of this study was to assess coinfection rates of coronavirus disease 2019 (COVID-19) with other respiratory infections on presentation.MethodsThis is a retrospective analysis of data from a 2 hospital academic medical centers and 2 urgent care centers during the initial 2 weeks of testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 10, 2020 to March 23, 2020. Testing was targeted toward high-risk patients following US Centers for Disease Control and Prevention guidelines. Demographics include age group and sex. Laboratory test results included SARS-CoV-2, rapid influenza A/B, and upper respiratory pathogen nucleic acid detection. Patient demographics and coinfections are presented overall and by test results with descriptive statistics.ResultsComplete laboratory results from the first 2 weeks of testing were available for 471 emergency department patients and 117 urgent care center patients who were tested for SARS-CoV. A total of 51 (8.7%) patients tested positive for COVID-19 with only 1 of these patients also testing positive for another respiratory infection. One of the patients positive for COVID-19 also tested positive for influenza A. Among the 537 patients who were screened and tested negative for COVID-19, there were 33 (6.1%) patients who tested positive in the upper respiratory pathogen nucleic acid detection test.ConclusionIn our study investigating coinfections among 51 patients testing positive for COVID-19, 1 patient also tested positive for influenza A. Although we found limited coinfections in our emergency department and urgent care center patient populations, further research is needed to assess potential coinfection in patients with COVID-19.