Risk factors for hepatitis C virus infection among blood donors in northern Thailand
Risk factors for hepatitis C virus infection among blood donors in northern Thailand
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DOI：
10.1111/j.1537-2995.2004.04073.x
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发表时间：
2004-10-01
期刊：
影响因子：
2.9
通讯作者：
Nelson, KE
中科院分区：
文献类型：
--
作者：
Thaikruea, L;Thongsawat, S;Nelson, KE
背景技术背景：丙型肝炎病毒（HCV）感染的流行病学，病毒学和危险因素在泰国北方献血者之间没有得到广泛的evaluated.Study设计和方法：我们做了一个前瞻性匹配的病例对照研究，献血者谁测试为HCV阳性，并通过重组免疫印迹试验或核酸检测确认。受感染的供体与1 - 4名未感染HCV的供体在性别、年龄5岁和HCV阳性供体15天内在同一地点献血方面相匹配。已婚献血者被邀请把他们的配偶为HCVtest.RESULTS：在166个匹配的集，静脉吸毒史（IDU），58 HCV感染的捐助者（35.5%）和2 HCV阴性的捐助者，是强相关的HCV感染（比值比[OR]，107.6，95%置信区间，14.8-780.7）。在无IDU病史的献血者中进行的多变量分析中，显著的危险因素包括输血史（OR，28.8）、有肝炎/黄疸史的直系亲属（OR，4.4）、6个或更多的终生性伴侣（OR，2.7）和献血频率增加（OR，0.9）。6 45个配偶的HCV感染的捐助者，没有44个配偶的未感染的捐助者，HCV阳性（p = 0.005）。结论：我们的数据表明，非法注射吸毒和输血史是重要的危险因素，在泰国的HCV感染。此外，我们的数据表明，通过性或配偶之间的其他密切接触可能存在一些传播风险。
BACKGROUND: The epidemiology, virology, and risk factors for hepatitis C virus (HCV) infection among blood donors in northern Thailand have not been extensively evaluated.STUDY DESIGN AND METHODS: We did a prospective matched case-control study of blood donors who tested positive for HCV and were confirmed by recombinant immunoblot assay or nucleic acid testing. Infected donors were matched with one to four HCV-uninfected donors for sex, age 5 years, and donation at the same site within 15 days of the HCV-positive donor. Married donors were invited to bring their spouse for HCV testing.RESULTS: Among 166 matched sets, a history of intravenous drug use (IDU), reported by 58 HCV infected donors (35.5%) and 2 HCV-negative donors, was strongly associated with HCV infection (odds ratio [OR], 107.6; 95% confidence interval, 14.8-780.7). In multivariate analysis among donors without a history of IDU, significant risk factors included a history of a blood transfusion (OR, 28.8), immediate family with a history of hepatitis/jaundice (OR, 4.4), six or more lifetime sexual partners (OR, 2.7), and increased frequency of blood donation (OR, 0.9). Six of 45 spouses of HCV-infected donors, and none of 44 spouses of uninfected donors, were HCV positive (p = 0.005).CONCLUSION: Our data indicate that illicit IDU and a history of transfusion are important risk factors for HCV infection in Thailand. Also, our data suggest there may be some risk of transmission by sex or other close contact between spouses.