DISTRIBUTION AND RELEASE OF HUMAN PANCREATIC POLYPEPTIDE
DISTRIBUTION AND RELEASE OF HUMAN PANCREATIC POLYPEPTIDE
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DOI：
10.1136/gut.17.12.940
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发表时间：
1976-01-01
期刊：
影响因子：
24.5
通讯作者：
BARNES, AJ
中科院分区：
文献类型：
--
作者：
ADRIAN, TE;BLOOM, SR;BARNES, AJ
一种简单可靠的放射免疫测定方法已被开发出来用于检测一种新的肠道激素HPP。在灵长类动物中，总PP的93%在胰腺中发现，其余的胃肠道中有少量。HPP已被证明是由许多胰腺腺瘤及其转移产生的。来自这些肿瘤和正常胰腺的免疫反应性PP与纯肽在色谱上难以区分。正常受试者餐后血浆PP浓度迅速升高，6小时后仍升高。胰内分泌肿瘤患者的空腹血浆PP水平甚至高于正常受试者的餐后水平。因此，PP测量对胰腺内分泌肿瘤的诊断是有用的。
A simple and reliable radioimmunoassay has been developed for a new gut hormone, HPP. In the primate 93% of the total PP was found in the pancreas with a small amount throughout the remaining gastrointestinal tract. HPP has been shown to be produced by a number of pancreatic apudomas and their metastases. The immunoreactive PP from these tumours and from normal pancreas was chromatographically indistinguishable from the pure peptide. The plasma PP concentration rose rapidly after a meal in normal subjects and was still raised six hours later. Fasting plasma PP levels in patients with PP cell containing pancreatic endocrine tumours were higher than even the postprandial level in normal subjects. PP measurements is thus useful in diagnosis of pancreatic endocrine tumours.