Genome-wide association study identifies loci and candidate genes for internal organ weights in Simmental beef cattle
Genome-wide association study identifies loci and candidate genes for internal organ weights in Simmental beef cattle
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全基因组关联研究确定了西门塔尔肉牛内脏重量的位点和候选基因
DOI：
10.1152/physiolgenomics.00022.2018
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发表时间：
2018-07-01
影响因子：
4.6
通讯作者：
Gao, Huijiang
中科院分区：
文献类型：
--
作者：
An, Bingxing;Xia, Jiangwei;Gao, Huijiang
牛内脏作为可获得的原料，在牛肉加工中的应用由来已久。饲料和制药行业。这些特征不仅对育种者具有经济利益，而且与许多有价值的特征有着内在的联系。例如增长、健康和生产力。使用Illumina牛盖770K SNP阵列。我们进行了一项全基因组范围的心脏重量、肝脏重量、脾重量的相关性研究。1,217头西门塔尔牛的肺重和肾重。在我们的研究中，发现了38个显著的单核苷酸多态(SNPs)(P<；1.49x10(-6))，用于5个内脏重量性状。这些SNP位于或接近13个基因，其中一些是以前报道过的。包括NDUFAF4、LCORL、8T 949 9 X6、SLIT2、FAMI84B、LAP3、BBSI2、Mecom、CD300LF、Hsd17b3、TLR4、MXII和MB2ID2。此外，我们在BTA6上检测到四个单倍型区块，其中包含18个与脾重量相关的显著SNPs。我们的研究结果为了解内脏器官发育的遗传机制提供了有价值的见解，在西门塔尔肉牛的育种中具有潜在的应用价值。
Cattle internal organs as accessible raw materials have a long history of being widely used in beef processing. feed and pharmaceutical industry. These traits not only are of economic interest to breeders, but they are intrinsically linked to many valuable traits. such as growth, health, and productivity. Using the Illumina Bovine LID 770K SNP array. we performed a genome-wide association study for heart weight, liver weight, spleen weight. lung weight, and kidney weight in 1,217 Simmental cattle. In our research, 38 significant single nucleotide polymorphisms (SNPs) (P < 1.49 x 10(-6)) were identified for five internal organ weight traits. These SNPs are within or near 13 genes, and some of them have been reported previously. including NDUFAF4, LCORL, 8T 949 9 X6, SLIT2, FAMI84B, LAP3, BBSI2, MECOM, CD300LF, HSD17B3, TLR4, MXII, and MB2ID2. In addition, we detected four haplotype blocks on BTA6 containing 18 significant SNPs associated with spleen weight. Our results offer worthy insights into understanding the genetic mechanisms of internal organs' development, with potential application in breeding programs of Simmental beef cattle.