Clinical implications of idiopathic multicentric Castleman disease among Japanese: A report of 28 cases
Clinical implications of idiopathic multicentric Castleman disease among Japanese: A report of 28 cases
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DOI：
10.1177/1066896908315812
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发表时间：
2008-10-01
影响因子：
1.2
通讯作者：
Nakamura, Shigeo
中科院分区：
文献类型：
--
作者：
Kojima, Masaru;Nakamura, Naoya;Nakamura, Shigeo
为了阐明日本人特发性多中心Castleman病的临床病理特征，我们对28例进行了研究。根据临床病理结果描述了两种变体（1）特发性浆细胞淋巴结病伴多克隆高免疫球蛋白血症（n = 18）和（2）非特发性浆细胞淋巴结病伴多克隆高免疫球蛋白血症（n = 10）。临床病理上，特发性浆细胞淋巴结病的定义是突出的多克隆高免疫球蛋白血症，正常的生发中心，和浆细胞在淋巴结滤泡间区域的片状浸润。组织学上，非特发性浆细胞性淋巴结病型的特征是淋巴结病变的透明血管生发中心。与特发性浆细胞性淋巴结病相比，非特发性浆细胞性淋巴结病患者很少出现显著的多克隆高免疫球蛋白血症，且常与自身免疫性疾病相关。但两种亚型的5年总生存率无差异。与特发性多中心Castleman病相比，日本的Castleman病似乎与人类疱疹病毒8感染阴性有关。
To clarify the clinicopathologic findings of idiopathic multicentric Castleman disease among Japanese, 28 cases were studied. Two variants were delineated by the clinicopathologic findings (1) idiopathic plasmacytic lymphadenopathy with polyclonal hyperimmunoglobulinemia (n = 18) and (2) nonidiopathic plasmacytic lymphadenopathy with polyclonal hyperimmunoglobulinemia (n = 10). Clinicopathologically, idiopathic plasmacytic lymphadenopathy was defined by the prominent polyclonal hyperimmunoglobulinemia, normal germinal centers, and sheet-like infiltration of plasma cells in the interfollicular area of the lymph node. Histologically, the nonidiopathic plasmacytic lymphadenopathy type was characterized by hyaline-vascular germinal centers of the lymph node lesion. In comparison with idiopathic plasmacytic lymphadenopathy, patients with nonidiopathic plasmacytic lymphadenopathy showed infrequent prominent polyclonal hyper-immunoglobulinemia and frequent association with autoimmune disease. However, there was no difference int he overall 5-year survival between the 2 subtypes. Compared with idiopathic multicentric Castleman disease in Japan appears to be related to negativity for human herpesvirus 8 infection.