Cortical cataract development--an expression of primary damage to the lens epithelium.
Cortical cataract development--an expression of primary damage to the lens epithelium.
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发表时间：
1989
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影响因子：
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通讯作者：
B. Worgul;George R. Merriam;C. Medvedovsky
中科院分区：
文献类型：
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作者：
B. Worgul;George R. Merriam;C. Medvedovsky
由于皮质混浊构成了老年性白内障的大部分，因此一个多世纪以来，其发病机制一直是人们研究关注的问题。越来越多的证据表明晶状体上皮在皮质透明度丧失中起主要作用。实验工作和临床经验的数据与晶状体上皮细胞基因组的原发性损伤一致。这种损伤是由晶状体纤维细胞的异常分化介导的，这些细胞共同表现为白内障。本文回顾了其中一些证据，并对与病理学相关的细胞参数的贡献方面进行了初步分析。此外，还讨论了“白内障毒性负荷”的概念及其对人类老年性皮质白内障发生的适用性。
Inasmuch as cortical opacities constitute the majority of senile cataracts their pathogenesis has been a matter of investigative concern for over a century. Evidence has been accumulating indicating a primary role for the lens epithelium in the loss of transparency of the cortex. Data from experimental work and clinical experience are consistent with a primary damage to the genome of the lens epithelial cell. The damage is mediated by the aberrant differentiation of lens fiber cells which collectively express as a cataract. The present paper reviews some of that evidence and offers preliminary analysis of the contributing aspects of cellular parameters associated with the pathology. Also, the concept of the "cataractotoxic load" and its applicability to the development of human senile cortical cataracts is discussed.