Profound amnesia after damage to the medial temporal lobe: A neuroanatomical and neuropsychological profile of patient E.P.
Profound amnesia after damage to the medial temporal lobe: A neuroanatomical and neuropsychological profile of patient E.P.
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DOI：
10.1523/jneurosci.20-18-07024.2000
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发表时间：
2000-09-15
影响因子：
5.3
通讯作者：
Squire, LR
中科院分区：
文献类型：
--
作者：
Stefanacci, L;Buffalo, EA;Squire, LR
E. 1992年，病毒性脑炎损害了他的内侧颞叶，之后他患上了严重的健忘症。由于这类患者的罕见性，我们对E。P.的病变使用磁共振成像，我们已经评估了他的认知能力与广泛的神经心理测试。最后，我们比较和对比了E。与著名的健忘症患者H.M，其手术损伤与E. P.的病变。
E. P. became profoundly amnesic in 1992 after viral encephalitis, which damaged his medial temporal lobe bilaterally. Because of the rarity of such patients, we have performed a detailed neuroanatomical analysis of E. P.'s lesion using magnetic resonance imaging, and we have assessed his cognitive abilities with a wide range of neuropsychological tests. Finally, we have compared and contrasted the findings for E. P. with the noted amnesic patient H.M, whose surgical lesion is strikingly similar to E. P.'s lesion.