Muscle Fatigue-Alleviating Effects of a Prescription Composed of Polygonati Rhizoma and Notoginseng Radix et Rhizoma.
Muscle Fatigue-Alleviating Effects of a Prescription Composed of Polygonati Rhizoma and Notoginseng Radix et Rhizoma.
复制标题
黄精、三七复方的缓解肌肉疲劳作用。
DOI：
10.1155/2020/3963045
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Xing-Xin Yang
中科院分区：
文献类型：
--
作者：
Ya-Qin Yang;Yan-Qin Li;Li-Ping Yu;Xue Li;Jian-Kang Mu;Jin Shang;Wen Gu;Jing-Ping Li;Jie Yu;Xing-Xin Yang
长期的肌肉疲劳是造成损伤的一个重要原因。预防疲劳的草药药物/营养素仍然是主要的研究焦点。在我国，黄精、三七复方已作为中药和食品营养品在临床上常用，具有抗疲劳作用。迄今为止，这种处方预防疲劳的机制尚不清楚。在这里，我们根据能量和氧化调节确定了该处方对肌肉疲劳的影响。通过负重力竭游泳产生疲劳小鼠模型。给小鼠灌胃处方提取物（1 和 2 g/kg）四个星期。调查力竭游泳次数、抗疲劳生化指标、氧化状态和能量代谢的变化。该处方延长了小鼠力竭游泳的时间。经该方治疗后，血清中乳酸、血尿素氮含量也明显降低。血清中肝糖原、乳酸脱氢酶含量升高。该处方还显着降低了丙二醛水平，增加了超氧化物歧化酶和谷胱甘肽过氧化物酶的水平。ATP酶、后腿骨骼肌线粒体中的复合物I和II以及血清肌酸激酶的水平也随着该处方而增加。结果表明，该方可通过促进能量代谢和抗氧化能力，有效缓解肌肉疲劳状态。因此，该处方代表了缓解肌肉疲劳的有用药物/营养策略。
Long-term muscle fatigue is a major cause of injury. Drugs/nutrients from herbal medicines that prevent fatigue remain a major.research focus. In China, a prescription composed of Polygonati Rhizoma and Notoginseng Radix et Rhizoma has been.commonly used as a herb and food nutrient, providing protection against fatigue in the clinic. To date, the mechanisms through.which this prescription prevented fatigue are unknown. Here, we identified the effects of this prescription on muscle fatigue.based on energy and oxidation regulation. Fatigue mouse models were produced through weight-bearing exhaustive swimming..Mice were intragastrically administered prescription extracts (1 and 2 g/kg) for four weeks. Changes in exhaustive swimming.times, antifatigue biochemical indicators, oxidative status, and energy metabolism were investigated. The prescription prolonged.the exhaustive swimming time of the mice. The content of lactic acid and blood urea nitrogen in the serum was also markedly.reduced by the prescription. The content of liver glycogen and lactate dehydrogenase in the serum increased. The prescription.also significantly reduced malondialdehyde levels and increased the levels of superoxide dismutase and glutathione peroxidase..The levels of ATPase, complexes I and II in the mitochondria of hind-leg skeletal muscle, and serum creatine kinase also.increased in response to the prescription. Our results indicated that the prescription could effectively alleviate muscle fatigue.status by promoting energy metabolism and antioxidation ability. The prescription therefore represents a useful drug/nutrient.strategy to alleviate muscle fatigue.