The neuroscience of recovery and rehabilitation: what have we learned from animal research?
The neuroscience of recovery and rehabilitation: what have we learned from animal research?
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DOI：
10.1053/apmr.2003.50146
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发表时间：
2003-04
影响因子：
4.3
通讯作者：
L. Turkstra;A. Holland;G. Bays
中科院分区：
文献类型：
--
作者：
L. Turkstra;A. Holland;G. Bays
鼓励康复专家对与人类神经康复相关的动物研究文献进行批判性研究，并鼓励临床医生将他们的观点用于基础研究。ATA来源：MEDLINE，PubMed和PsychInfo引用的科学出版物，以及领先的神经科学研究人员的专业演讲。重点是2001年以前的出版物，并酌情包括历史著作。研究选择研究根据其与目标的相关性进行选择。资料提炼回顾了研究方法和结果，并提取了与康复相关的关键原则。资料综合神经科学研究中出现的许多主题都与人类康复有关，包括与干预和恢复的时机有关的问题，以及神经系统可塑性的特征。尽管动物研究有许多局限性，但它为神经系统恢复提供了一个独特的窗口，并为未来的人类研究提供了重要的方向。临床医生参与基础动物研究将提高结果与人类康复和恢复相关的程度。
OBJECTIVES To encourage rehabilitation specialists to develop a critical approach to the animal research literature that is relevant to human neurorehabilitation and to encourage clinicians to lend their perspectives to basic research. ATA SOURCES: Scientific publications cited in MEDLINE, PubMed, and PsychInfo, and professional presentations of leading neuroscience researchers. The focus was on current publications to 2001, with historical works included when appropriate. STUDY SELECTION Studies were selected based on their relevance to the objectives. DATA EXTRACTION Reviewed study methodology and findings and extracted key principles relevant to rehabilitation. DATA SYNTHESIS Many themes emerging from neuroscience research are relevant to human rehabilitation, including issues related to timing of intervention and recovery, and characteristics of nervous system plasticity. CONCLUSIONS Although animal research has many limitations, it provides a unique window on nervous system recovery and has generated important directions for future human research. Clinician involvement in basic animal research will improve the extent to which results are relevant to human rehabilitation and recovery.