Epidemiology, Clinical Features, and Disease Severity in Patients With Coronavirus Disease 2019 (COVID-19) in a Children's Hospital in New York City, New York
Epidemiology, Clinical Features, and Disease Severity in Patients With Coronavirus Disease 2019 (COVID-19) in a Children's Hospital in New York City, New York
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DOI：
10.1001/jamapediatrics.2020.2430
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发表时间：
2020-10-01
期刊：
影响因子：
26.1
通讯作者：
Saiman, Lisa
中科院分区：
文献类型：
--
作者：
Zachariah, Philip;Johnson, Candace L.;Saiman, Lisa
关键点问题2019年(新冠肺炎)入院的儿童青少年冠状病毒病有哪些临床表现？在这一系列的病例中，有50名因新冠肺炎感染住院的儿童和青少年，虽然呼吸道症状很常见，但并不总是出现。接受新冠肺炎治疗的儿童通常会合并疾病，婴儿的病情不那么严重，肥胖者可能需要接受机械通气，入院时和住院期间炎症标志物的升高与严重疾病有关。这意味着，鉴于新冠肺炎的不同表现形式，保持对严重急性呼吸综合征冠状病毒2型感染的高度怀疑，以及认识到暗示免疫失调的发现，这对于儿童有效的新冠肺炎管理至关重要。重要说明儿科冠状病毒疾病2019(新冠肺炎)经验的描述将有助于为儿科机构的临床实践和感染预防和控制提供信息。目的描述儿童医院新冠肺炎患者的流行病学、临床和实验室特征，并比较重症患者与非重症患者的相关指标。设计、设置和参与者这项对纽约市一家三级保健附属儿童医院的电子病历的回顾，包括住院的儿童和青少年(
Key PointsQuestionWhat are the clinical manifestations of children and adolescents hospitalized with coronavirus disease 2019 (COVID-19)? FindingsIn this case series of 50 children and adolescents hospitalized with COVID-19 infection, respiratory symptoms, while common, were not always present. Children hospitalized with COVID-19 commonly had comorbidities, infants had less severe disease, those with obesity were likely to receive mechanical ventilation, and elevated markers of inflammation at admission and during hospitalization were associated with severe disease. MeaningExpanded testing, maintaining a high suspicion for severe acute respiratory syndrome coronavirus 2 infection given the variable presentation of COVID-19, risk stratification, and recognition of findings suggestive of immune dysregulation are crucial to effective COVID-19 management in children.ImportanceDescriptions of the coronavirus disease 2019 (COVID-19) experience in pediatrics will help inform clinical practices and infection prevention and control for pediatric facilities. ObjectiveTo describe the epidemiology, clinical, and laboratory features of patients with COVID-19 hospitalized at a children's hospital and to compare these parameters between patients hospitalized with and without severe disease. Design, Setting, and ParticipantsThis retrospective review of electronic medical records from a tertiary care academically affiliated children's hospital in New York City, New York, included hospitalized children and adolescents (