Efficacy of 7-valent pneumococcal conjugate vaccination in Germany: An analysis using the indirect cohort method
Efficacy of 7-valent pneumococcal conjugate vaccination in Germany: An analysis using the indirect cohort method
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DOI：
10.1016/j.vaccine.2010.05.021
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发表时间：
2010-07-12
期刊：
影响因子：
5.5
通讯作者：
von Kries, Rildiger
中科院分区：
文献类型：
--
作者：
Rueckinger, Simon;van der Linden, Mark;von Kries, Rildiger
在两岁以下儿童中使用4剂疫苗接种计划的随机对照试验显示，7价肺炎球菌结合疫苗的有效性。来自美国的一项病例对照研究表明，减少疫苗接种时间表，甚至只接种一剂疫苗，对IPD有相当大的保护作用。在德国，延迟和不完整的疫苗接种是一个主要问题。我们使用主动监测的IPD病例数据和Broome提出的间接队列设计来评估PCV7的疗效。比较具有疫苗血清型与非疫苗血清型的IPD病例。至少一剂PCV7的有效率估计为88.3% （95% CI: 64.0-96.6）。在生命的前7个月，一剂、二剂和三剂的估计疗效分别为78.1%（3.4-96.1）、89.8%（20.6-100.0）和94.6%（69.7-99.5）。我们的研究为减少PCV7疫苗接种时间表提供了更好的保护证据，例如，在高比例儿童延迟接种疫苗的情况下，将两次剂量作为初级系列。(C) 2010 Elsevier Ltd.版权所有。
Efficacy of 7-valent pneumococcal conjugate vaccination has been shown in randomized controlled trials using 4 dose vaccination schedules in children under 2 years of age. A case-control study from the US showed considerable protection from IPD for reduced vaccination schedules and even some protection from only one dose. In Germany, delayed and incomplete vaccination is a major issue. We assessed efficacy of PCV7 using data on cases of IPD from active surveillance and applying the indirect cohort design proposed by Broome. comparing cases of IPD with a vaccine serotype with cases with a non-vaccine serotype. Efficacy of at least one dose of PCV7 was estimated to be 88.3% (95% CI: 64.0-96.6). Estimates of efficacy for one, two, and three doses in the first 7 months of life were 78.1% (3.4-96.1), 89.8% (20.6-100.0), and 94.6% (69.7-99.5) respectively. Our study adds to evidence of good protection from IPD by reduced vaccination schedules with PCV7, e.g. with two doses as primary series, in a setting where a high proportion of children receives vaccination delayed. (C) 2010 Elsevier Ltd. All rights reserved.