Stromal cells can contribute oncogenic signals
Stromal cells can contribute oncogenic signals
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DOI：
10.1006/scbi.2000.0361
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发表时间：
2001-04-01
影响因子：
14.5
通讯作者：
Tlsty, TD
中科院分区：
文献类型：
--
作者：
Tlsty, TD
大多数肿瘤转化的研究都集中在转化细胞内发生的事件。这些细胞自主事件导致调节细胞基本活动（如增殖、死亡、运动和基因组完整性）的分子途径的破坏。其他研究已经解决了肿瘤细胞的微环境，并记录了其在支持肿瘤进展中的重要性。最近的工作已经开始扩大这些肿瘤微环境的初步研究，现在提供了新的见解，可能的启动和恶性细胞的进展。本文就基质细胞对上皮成分的转化作用作一综述。
The majority of studies of neoplastic transformation have focused attention on events that occur within transformed cells. These cells autonomous events result in the disruption of molecular pathways that regulate basic activities of the cells such as proliferation, death, movement and genomic integrity. Other studies have addressed the microenvironment of tumor cells and documented its importance in supporting tumor progression. Recent work has begun to expand on these initial studies of tumor microenvironment and now provide novel insights into the possible initiation and progression of malignant cells. This review will address the transforming effect of stromal cells on epithelial components.