THE EMBRYONIC-DEVELOPMENT OF THE DROSOPHILA VISUAL-SYSTEM
THE EMBRYONIC-DEVELOPMENT OF THE DROSOPHILA VISUAL-SYSTEM
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DOI：
10.1007/bf00333712
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发表时间：
1993-09-01
影响因子：
3.6
通讯作者：
HARTENSTEIN, V
中科院分区：
文献类型：
--
作者：
GREEN, P;HARTENSTEIN, AY;HARTENSTEIN, V
我们已经使用电子显微镜研究，溴脱氧尿苷（BrdU）掺入和抗体标记的特点发展的果蝇幼虫感光（或Bolwig的）器官和视叶，并已调查的作用，Notch在两者的发展。视叶和Bolwig氏器是从头前区后内陷而成。在该区域的细胞经历四次后胚盘分裂后，总共约85个细胞内陷。视叶内陷与胚胎的外表面失去接触，形成附着在大脑上的上皮囊泡。Bolwig的器官来自视叶内陷的近腹部分，但并不并入视叶;相反，它的12个细胞保留在头部表皮中，直到胚胎发育后期，当它们与头部内卷一起移动到咽旁的最终位置时。早期，在头部退化之前，Bolwig器官的细胞形成了一个由7个细胞组成的“玫瑰花结”模式的浅层组和一个由5个细胞组成的深层组。随后，所有神经元移出表面上皮。与成年光感受器不同，它们不形成杆粒;相反，它们产生多个分支的过程，可能携带色素。Notch对视觉系统早期发育的两个方面至关重要。首先，它界定了纳入Bolwig器官的细胞数量。第二，它是维持视叶细胞的上皮特性，在其内陷期间和之后所必需的。
We have used electron-microscopic studies, bromodeoxyuridine (BrdU) incorporation and antibody labeling to characterize the development of the Drosophila larval photoreceptor (or Bolwig's) organ and the optic lobe, and have investigated the role of Notch in the development of both. The optic lobe and Bolwig's organ develop by invagination from the posterior procephalic region. After cells in this region undergo four postblastoderm divisions, a total of approximately 85 cells invaginate. The optic lobe invagination loses contact with the outer surface of the embryo and forms an epithelial vesicle attached to the brain. Bolwig's organ arises from the ventralmost portion of the optic lobe invagination, but does not become incorporated in the optic lobe; instead, its 12 cells remain in the head epidermis until late in embryogenesis when they move in conjunction with head involution to reach their final position alongside the pharynx. Early, before head involution, the cells of Bolwig's organ form a superficial group of 7 cells arranged in a 'rosette' pattern and a deep group of 5 cells. Later, all neurons move out of the surface epithelium. Unlike adult photoreceptors, they do not form rhabdomeres; instead, they produce multiple, branched processes, which presumably carry the photopigment. Notch is essential for two aspects of the early development of the visual system. First, it delimits the number of cells incorporated into Bolwig's organ. Second, it is required for the maintenance of the epithelial character of the optic lobe cells during and after its invagination.