Comparison of histologic subtype and growth pattern in intraductal papillary-mucinous carcinoma of the pancreas.
Comparison of histologic subtype and growth pattern in intraductal papillary-mucinous carcinoma of the pancreas.
复制标题
胰腺导管内乳头状粘液癌组织学亚型和生长模式的比较。
DOI：
--
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Kazuhiro Yoshida
中科院分区：
文献类型：
--
作者：
Y. Sanada;S. Kunita;Kazuhiro Yoshida
本研究的目的是通过组织病理学和免疫组织化学比较主要导管型导管内乳头状粘液癌（IPMC）的组织学亚型和生长模式，包括浸润和导管内扩散到支管。本文对5例手术切除的主导管型IPMC进行了研究。显微镜下检查主要病变，浸润成分和邻近的次级导管。我们用单克隆粘蛋白2 （MUC2）和多克隆羊角酸磷酸核糖基转移酶（OPRT）抗体进行免疫组化。3例主导管内可见腺瘤成分。其中两例显示肠型伴导管内扩散至支管，支管的肿瘤改变包括MUC2阳性的高级别胰腺上皮内瘤样导管和充满树突状肿瘤细胞的导管，类似于胰胆管型。另1例显示主导管胃型腺瘤和肠型原位癌（CIS），小管浸润。其余2例主导管未见腺瘤成分，但表现为正常上皮向CIS（胰胆型或嗜瘤细胞型）的突然转变，OPRT显示大量浸润弥漫性阳性。这些结果表明，在主导管中有腺瘤成分的IPMC可以在导管内扩散到分支导管，具有低的恶性潜能。一种亚型向另一种亚型的进展与导管内乳头状粘液瘤（IPMN）的导管内扩散有关。然而，没有腺瘤成分的IPMC与明显的侵袭相关。
The purpose of this study was to compare histologic subtype and growth pattern, including invasion and intraductal spread to branch ducts, in main duct-type intraductal papillary-mucinous carcinoma (IPMC) by histopathology and immunohistochemistry. Five surgically resected samples of main duct-type IPMC from five patients, were studied. Main lesions, invasive components, and adjacent secondary ducts were examined microscopically. We performed immunohistochemistry with monoclonal mucin 2 (MUC2) and polyclonal orotate phosphoribosyltransferase (OPRT) antibodies. Three cases showed adenoma components in the main duct. Two of these showed intestinal-type accompanied by intraductal spread to branch ducts, neoplastic changes in branch ducts consisting of high-grade pancreatic intraepithelial neoplasia-like ducts positive for MUC2, and ducts filled with arborizing neoplastic cells, resembling pancreatobiliary type. The other case showed gastric-type adenoma and intestinal-type carcinoma in situ (CIS) in the main duct, with minimal tubular invasion. The two remaining cases showed no adenoma components in the main duct, but showed abrupt transition from normal epithelium to CIS (pancreatobiliary type or oncocytic type) and massive invasion diffusely positive for OPRT. These results suggest that IPMC with adenoma components in the main duct undergoes intraductal spread to branch ducts and has low malignant potential. The progression of one subtype to another is associated with intraductal spread of intraductal papillary-mucinous neoplasm (IPMN). However, IPMC without adenoma components is associated with marked invasion.
胰腺上皮内瘤变的肠和嗜酸细胞变异。
DOI：
10.1016/j.anndiagpath.2004.12.002
发表时间：
2005
期刊：
Annals of diagnostic pathology.
影响因子：
--
作者：
Albores-Saavedra,Jorge;Wu,Jianhua;Crook,Terri;Amirkhan,RobinH;Jones,Lamar;Hruban,RalphH
通讯作者：
Hruban,RalphH