Family history and prostate cancer risk
Family history and prostate cancer risk
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DOI：
10.1093/oxfordjournals.aje.a008876
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发表时间：
1996-12-01
影响因子：
5
通讯作者：
Shapiro, S
中科院分区：
文献类型：
--
作者：
Lesko, SM;Rosenberg, L;Shapiro, S
作者于 1992 年 12 月至 1994 年 10 月在马萨诸塞州进行了一项基于人群的病例对照研究，研究了前列腺癌家族史与患这种癌症的风险之间的关系。病例均为 70 岁以下男性的前列腺癌发病病例 (n = 563)；对照组是没有疾病史的男性，其年龄和居住城镇与病例相匹配（n = 703）。报告其父亲或兄弟有前列腺癌病史的男性患前列腺癌的风险增加（比值比 (OR) = 2.3，95% 置信区间 (CI) 1.7-3.3）。风险因受影响亲属的数量及其与病例的关系而异。对于一名亲属有前列腺癌病史，OR 为 2.2 (95% CI 1.5-3.2)；如果有两个或更多亲属受累，则为 3.9 (95% CI 1.7-5.2)，对于父亲患有前列腺癌，OR 为 1.9 (95% CI 1.2-3.0)；对于兄弟的前列腺癌，该值为 3.0 (95% CI 1.8-4.9)。风险与受试者的年龄以及其患病亲属诊断出前列腺癌的年龄呈负相关。在年龄小于 60 岁的先证者中，OR 为 5.3 (95% CI 2.5-12)；对于 60-64 岁的人群，OR 为 2.7（95% CI 1.3-5.5）；对于 65 岁及以上的人，OR 为 1.6 (95% CI 1.0-2.5)。对于 65 岁之前的亲属诊断出的前列腺癌，OR 为 4.1 (95% CI 2.3-7.3)； 74 岁以后检测该疾病的 OR 为 0.76 (95% CI 0.38-1.5)。这种关联既存在于患有局部和晚期疾病的男性中，也存在于通过筛查或因症状而检测出前列腺癌的男性中。这些数据提供的证据表明，在控制饮食和其他潜在混杂因素后，家族因素与前列腺癌的风险显着相关。
The authors examined the relation between family history of prostate cancer and the risk of this cancer in a population-based case-control study conducted in Massachusetts between December 1992 and October 1994. Cases were all incident cases of prostate cancer in men younger than 70 years (n = 563); controls were men with no history of the disease matched to the cases on age and town of residence (n = 703). Prostate cancer risk was increased among men who reported a history of this cancer in either their fathers or brothers (odds ratio (OR) = 2.3, 95% confidence interval (CI) 1.7-3.3). Risk varied with the number of relatives affected and their relationship to the case, For a history of prostate cancer in one relative, the OR was 2.2 (95% CI 1.5-3.2); if two or more relatives were affected, it was 3.9 (95% CI 1.7-5.2), For prostate cancer in the father, the OR was 1.9 (95% CI 1.2-3.0); for prostate cancer in a brother, it was 3.0 (95% CI 1.8-4.9). Risk was inversely related to the subject's age and to age at diagnosis of prostate cancer in his affected relative. Among probands younger than 60 years, the OR was 5.3 (95% CI 2.5-12); for those 60-64 years of age, the OR was 2.7 (95% CI 1.3-5.5); and for those 65 years of age and older, the OR was 1.6 (95% CI 1.0-2.5). For prostate cancer diagnosed in a relative before age 65, the OR was 4.1 (95% CI 2.3-7.3); for detection of the disease after age 74, the OR was 0.76 (95% CI 0.38-1.5). The association was present both among men with local and advanced stage disease and among men whose prostate cancer was detected either by screening or because of symptoms. These data provide evidence that after controlling for diet and other potential confounders, familial factors are significantly associated with the risk of prostate cancer.