Total isothiocyanate yield from raw cruciferous vegetables commonly consumed in the United States.
Total isothiocyanate yield from raw cruciferous vegetables commonly consumed in the United States.
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DOI：
10.1016/j.jff.2013.07.011
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发表时间：
2013-10-01
影响因子：
5.6
通讯作者：
McCann, Susan E.
中科院分区：
文献类型：
--
作者：
Tang, Li;Paonessa, Joseph D.;Zhang, Yuesheng;Arnbrosone, Christine B.;McCann, Susan E.
关键词：
膳食异硫氰酸酯是一组有前途的化学预防剂，主要从十字花科蔬菜中获得。由于其有效的化学预防和/或抗癌活性，人们对评估膳食中异硫氰酸酯暴露及其对人类健康的影响越来越感兴趣。采用高效液相色谱法测定了生十字花科蔬菜中总异硫氰酸酯的含量。共分析了73个样品，包括9种十字花科蔬菜。我们观察到不同蔬菜中异硫氰酸盐的含量范围很广，平均水平为16.2 μmol/100 g湿重，从生花椰菜的1.5 μmol到生芥菜的61.3 μmol不等。这些数据代表了摄入生十字花科蔬菜释放的异硫氰酸酯的最大量。鉴于本研究中检测的蔬菜包括西方饮食中最常食用的十字花科蔬菜，这些数据可能对估计这些人群的膳食异硫氰酸盐暴露量特别有用。然而，由于在每种蔬菜中观察到的变化，生物标志物，如尿中异硫氰酸盐水平可能是必要的，以准确估计个人暴露。
Dietary isothiocyanates are a group of promising chemopreventive agents obtained primarily from cruciferous vegetables. Due to their potent chemopreventive and/or anti-cancer activities, there is a growing interest in assessing dietary isothiocyanate exposure and its impact on human health. Using the HPLC-based cyclocondensation assay, the current study measured total isothiocyanate yield from raw cruciferous vegetables. A total of 73 samples comprising nine types of cruciferous vegetables were analyzed. We observed a wide range of isothiocyanate content across the individual vegetables with an average level of 16.2 μmol/100g wet weight, ranging from 1.5 μmol in raw cauliflower to 61.3 μmol in raw mustard greens. The data represent the maximum amount of isothiocyanates released from the intake of raw cruciferous vegetables. Given that the vegetables assayed in this study include the most commonly consumed cruciferous vegetables in western diets, the data may be particularly useful in estimation of dietary isothiocyanate exposure in these populations. However, due to the variation observed within each vegetable, biomarkers such as urinary isothiocyanate level may be necessary for accurate estimation of individual exposure.
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