Edible Flowers of Tagetes erecta L. as Functional Ingredients: Phenolic Composition, Antioxidant and Protective Effects on Caenorhabditis elegans
Edible Flowers of Tagetes erecta L. as Functional Ingredients: Phenolic Composition, Antioxidant and Protective Effects on Caenorhabditis elegans
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DOI：
10.3390/nu10122002
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发表时间：
2018-12-01
期刊：
影响因子：
5.9
通讯作者：
Gomez-Rincon, Carlota
中科院分区：
文献类型：
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作者：
Moliner, Cristina;Barros, Lillian;Gomez-Rincon, Carlota
万寿菊在不同的国家，长期以来一直被用于烹饪和药用目的。本研究的目的是探讨两个品种的潜在效益，T。与其多酚类以及抗氧化和抗衰老特性有关。采用LC-DAD-ESI/MSn分析了酚类化合物的组成。进行Folin-Ciocalteu、DPPH和FRAP测定以评价还原抗自由基性质。使用乙酰胆碱酯酶和单胺氧化酶评价神经保护潜力。秀丽隐杆线虫被用作体内模型来评估提取物毒性、抗氧化活性、延迟衰老和降低的淀粉样蛋白毒性。两种提取物显示出相似的酚类成分和生物活性。多酚类物质主要为落叶松素及其苷类。在C. elegans模型T.直立花提取物在不同的测试模型中显示出有希望的抗氧化和神经保护特性。因此，这些结果可能会增加一些信息，支持使用这些植物作为功能性食品和/或营养成分的可能性。
Tagetes erecta L. has long been consumed for culinary and medicinal purposes in different countries. The aim of this study was to explore the potential benefits from two cultivars of T. erecta related to its polyphenolic profile as well as antioxidant and anti-aging properties. The phenolic composition was analyzed by LC-DAD-ESI/MSn. Folin-Ciocalteu, DPPH, and FRAP assays were performed in order to evaluate reducing antiradical properties. The neuroprotective potential was evaluated using the enzymes acetylcholinesterase and monoamine oxidase. Caenorhabditis elegans was used as an in vivo model to assess extract toxicity, antioxidant activity, delayed aging, and reduced -amyloid toxicity. Both extracts showed similar phenolic profiles and bioactivities. The main polyphenols found were laricitin and its glycosides. No acute toxicity was detected for extracts in the C. elegans model. T. erecta flower extracts showed promising antioxidant and neuroprotective properties in the different tested models. Hence, these results may add some information supporting the possibilities of using these plants as functional foods and/or as nutraceutical ingredients.