Influence of autophagy on the efficacy of radiotherapy.
Influence of autophagy on the efficacy of radiotherapy.
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DOI：
10.1186/s13014-017-0795-y
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发表时间：
2017-03-21
期刊：
影响因子：
--
通讯作者：
Law HK
中科院分区：
文献类型：
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作者：
Tam SY;Wu VW;Law HK
自噬是细胞消化和循环自身细胞质内容物以维持细胞稳态的重要分解代谢过程。有趣的是，自噬可以通过各种信号通路在影响癌症的发展中发挥促死亡和促生存的作用。由于放射治疗是癌症的主要治疗方式之一，我们综述了自噬调节对不同类型癌症放射敏感性和放射治疗效果的影响。本文还将讨论自噬修饰在提高放疗疗效和癌症预后方面的未来发展。
Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-survival roles in influencing the development of cancer via various signal pathways. As radiotherapy is one of the main treatment modalities for cancer, we reviewed the effect of autophagy modulations on radiosensitivity and radiotherapy efficacy in various cancer types. The future development of autophagy modifications for improving radiotherapy efficacy and cancer prognosis will also be discussed.