Hybrid tumour 'oncocytoma-chromophobe renal cell carcinoma' of the kidney: a report of seven sporadic cases
Hybrid tumour 'oncocytoma-chromophobe renal cell carcinoma' of the kidney: a report of seven sporadic cases
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DOI：
10.1111/j.1464-410x.2008.08263.x
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发表时间：
2009-05-01
影响因子：
4.5
通讯作者：
Mejean, Arnaud
中科院分区：
文献类型：
--
作者：
Delongchamps, Nicolas B.;Galmiche, Louise;Mejean, Arnaud
为了确定肾杂合性肿瘤（HT）是否表现为一种特定的临床和放射学实体，因为HT的特征是在同一肿瘤中存在肿瘤细胞和嫌色细胞的关联，并且在嗜瘤性细胞增多症和Birt-Hogg-Dube综合征患者中已有描述。我们回顾了从2006年1月至2007年10月间，本院67例因肾嗜瘤细胞瘤（RO， 24例）、嗜色性肾细胞癌（CRCC， 36例）和HT（7例）而行部分或根治性肾切除术的患者的病历。我们报告7例HT的临床、影像学和病理特点。患者平均年龄（范围）为56岁（41-68岁）。根据计算机断层扫描（CT）， 7例患者均未怀疑有RO。2例患者有肾癌病史。5例患者行部分肾切除术，2例行根治性肾切除术。平均（范围）最大肿瘤直径为5.5 (1.8-9)cm， pT1a 2例，pT1b 2例，pT2 3例。病理分析显示ro样细胞和crcc样细胞混合（6例）或明显（1例）。在中位（范围）随访20（8-25）个月后，没有患者有任何疾病复发的迹象。在大量散发性RO和CRCC患者中，10%的肿瘤具有混合形态特征，如嗜瘤性增生和Birt-Hogg-Dube综合征所描述的。我们无法确定任何具体的临床特征。最重要的是，这些HT没有表现出任何RO的放射学特征。
To determine whether renal hybrid tumours (HT) appear as a specific clinical and radiological entity, as HT are characterized by the association of both oncocytes and chromophobe cells within the same tumour, and have been described in patients with oncocytosis and Birt-Hogg-Dube syndrome.We reviewed the medical charts of 67 patients who had a partial or radical nephrectomy in our institution for renal oncocytoma (RO, 24), chromophobe renal cell carcinoma (CRCC, 36) and HT (seven), from January 2006 to October 2007. We report the clinical, radiological and pathological characteristics of the seven cases of HT.The mean (range) age of the patients was 56 (41-68) year. None of the seven patients had any suspicion of RO, based on computed tomography (CT). Two patients had a history of kidney cancer. Five patients had partial and two a radical nephrectomy. The mean (range) maximum tumour diameter was 5.5 (1.8-9) cm. Two tumours were pT1a, two were pT1b and three were pT2. Pathological analysis showed RO-like and CRCC-like cells intermixed (six patients) or distinct (one). After a median (range) follow-up of 20 (8-25) months, none of the patients had any evidence of disease recurrence.In a large series of patients with sporadic RO and CRCC, 10% of the tumours had hybrid morphological features, as described in oncocytosis and Birt-Hogg-Dube syndrome. We were unable to identify any specific clinical characteristic. Most importantly, none of these HT showed any of the radiological characteristics of RO.