Childhood Asthma Inception and Progression Role of Microbial Exposures, Susceptibility to Viruses and Early Allergic Sensitization
Childhood Asthma Inception and Progression Role of Microbial Exposures, Susceptibility to Viruses and Early Allergic Sensitization
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DOI：
10.1016/j.iac.2018.12.001
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发表时间：
2019-05-01
影响因子：
2.6
通讯作者：
Martinez, Fernando D.
中科院分区：
文献类型：
--
作者：
Martinez, Fernando D.
对呼吸道病毒（尤其是鼻病毒）的不适当反应和早期过敏性致敏是早发性哮喘发生和持续的最重要因素。染色体17 q上的ORMDL3哮喘基因座似乎通过增加生命早期对人鼻病毒的易感性来发挥其作用。在动物农场饲养对哮喘的发展具有高度的保护作用，这种保护作用是通过接触微生物来介导的。两项针对高危幼儿的试验已经在进行中，一项使用细菌冻干物预防喘息性下呼吸道疾病，另一项使用抗免疫球蛋白E预防哮喘进展。
Inappropriate responses to respiratory viruses, especially rhinovirus, and early allergic sensitization are the strongest contributors to the inception and persistence of early onset asthma. The ORMDL3 asthma locus in chromosome 17q seems to exert its effects by increasing susceptibility to human rhinovirus in early life. Being raised on animal farms is highly protective against the development of asthma, and this protective effect is mediated by exposure to microbes. Two trials in high-risk young children, one to prevent wheezing lower respiratory tract illness using bacterial lyophilizates and another using anti-immunoglobulin E to prevent asthma progression, are already under way.