Characteristic alkaline catalyzed degradation of kotalanol, a potent α-glucosidase inhibitor isolated from Ayurvedic traditional medicine Salacia reticulata, leading to anhydroheptitols: another structural proof
Characteristic alkaline catalyzed degradation of kotalanol, a potent α-glucosidase inhibitor isolated from Ayurvedic traditional medicine Salacia reticulata, leading to anhydroheptitols: another structural proof
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DOI：
10.1016/j.tet.2010.03.072
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发表时间：
2010-05-22
期刊：
影响因子：
2.1
通讯作者：
Yoshikawa, Masayuki
中科院分区：
文献类型：
--
作者：
Muraoka, Osamu;Xie, Weijia;Yoshikawa, Masayuki
kotalanol（2）是一种从印度草药传统药物Salacia reticulata中分离的高效α-葡萄糖苷酶抑制剂，其立体化学结构通过碱催化降解天然kotalanol（2）得到证实，其中涉及导致脱水庚醇（10和11）的降解侧链的特征性立体特异性环化。(C)2010爱思唯尔有限公司版权所有。
Stereochemical structure of kotalanol (2), a highly potent a-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata, was proved by alkaline catalyzed degradation of natural kotalanol (2), in which characteristic stereospecific cyclization of the degradative side chain leading to anhydroheptitols (10 and 11) was involved. (C) 2010 Elsevier Ltd. All rights reserved.