Alkali-labile sites in biologically active DNA: comparison of radiation induced potential breaks and apurinic sites.

Alkali-labile sites in biologically active DNA: comparison of radiation induced potential breaks and apurinic sites.
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生物活性 DNA 中的碱不稳定位点:辐射诱导电位断裂和无嘌呤位点的比较。

DOI:
10.1080/09553008114550131
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发表时间:
1981
期刊:
International journal of radiation biology and related studies in physics, chemistry, and medicine
影响因子:
--
通讯作者:
H. Loman
H. Loman
中科院分区:
--
文献类型:
--
作者:
M. Lafleur;J. Woldhuis;H. Loman

文献摘要

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γ-射线诱导的碱不稳定位点,这是转化成断裂碱或热,与脱嘌呤位点在单链和phi X174 RF-DNA进行了比较。结果表明,转化为断裂的动力学是完全不同的两个网站。结论是:γ射线诱导的碱不稳定位点与脱嘌呤或/和脱嘧啶位点不完全相同。
Gamma-ray induced alkali-labile sites, which are converted into breaks by alkali or heat, are compared with apurinic sites in both single-stranded and phi X174RF-DNA. It is shown that the kinetics of the conversion into breaks are completely different for both sites. The conclusion is: the gamma-ray induced alkali-labile sites are not identical with apurinic or/and apyrimidinic sites.