Superhemophobic titania nanotube array surfaces for blood contacting medical devices
Superhemophobic titania nanotube array surfaces for blood contacting medical devices
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DOI：
10.1039/c7ra03373g
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发表时间：
2017-01-01
期刊：
影响因子：
3.9
通讯作者：
Popat, Ketul C.
中科院分区：
文献类型：
--
作者：
Bartlet, Kevin;Movafaghi, Sanli;Popat, Ketul C.
血液接触医疗器械的血液相容性是防止器械失效的必要条件。一旦物质遇到血液，蛋白质和血小板就会被吸附并附着在其表面。这导致血栓形成和在表面形成凝块，限制血液流动，在某些情况下导致炎症和设备故障。为了避免这些并发症，接受血液接触装置的患者必须服用血液稀释药物，这些药物必须在患者的余生中服用。有些设备可以预先凝血以改善血液相容性，但这种好处不会持续设备的整个生命周期。提高血液相容性是近年来研究的热点。提出的方法包括类金刚石碳表面、基于肝素的表面涂层、改性聚合物表面和二氧化钛纳米管阵列。这些方法最初都显示出一些血液相容性的增强，但没有一种方法被证明是长期持久的。超恐血表面是一种改善血液相容性的新方法，但血液成分与这些表面的相互作用尚未深入研究。在这项研究中，我们通过改变钛的表面形貌和表面化学来开发超疏血表面。通过阳极氧化技术制备二氧化钛纳米管阵列，对表面形貌进行了修饰。采用化学气相沉积的方法，用两种不同的硅烷修饰二氧化钛纳米管阵列，诱导其超疏血性。对血液与超恐血表面相互作用的研究表明，蛋白质吸附和血小板粘附/活化减少，表明这是一种增强材料血液相容性的潜在方法。
Hemocompatibility of blood-contacting medical devices is necessary to prevent device failure. As soon as a material encounters blood, proteins and platelets will adsorb and attach to its surface. This leads to thrombosis and clot formation on the surfaces, restricting blood flow and in some cases leading to inflammation and device failure. To avoid these complications, patients receiving blood-contact devices are prescribed blood thinning medications, which must be taken for the rest of the patient's life. Some devices can be pre-clotted to improve hemocompatibility, but the benefits will not last the device's entire life. Enhancing hemocompatibility has been a focus of recent research. Proposed methods have included diamond-like carbon surfaces, heparin-based surface coatings, modified polymer surfaces, and titania nanotube arrays. These methods have all shown some enhancement of hemocompatibility initially, but no approach has proven durable over long periods of time. Superhemophobic surfaces are a new approach to improving hemocompatibility, but the interactions of blood components with these surfaces have not been studied in depth. In this study, we have developed superhemophobic surfaces by modifying the surface topography and surface chemistry of titanium. The surface topography was modified by creating titania nanotube arrays through a well-documented anodization technique. Superhemophobicity was induced by modifying the titania nanotube arrays with two different silanes using chemical vapor deposition. The investigations of blood interactions with superhemophobic surfaces showed reduced protein adsorption and platelet adhesion/activation, indicating this a potential approach for enhancing material hemocompatibility.