Persistent RNA virus infections: do PAMPS drive chronic disease?
Persistent RNA virus infections: do PAMPS drive chronic disease?
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DOI：
10.1016/j.coviro.2017.01.003
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发表时间：
2017-04-01
影响因子：
5.9
通讯作者：
Morrison, Thomas E.
中科院分区：
文献类型：
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作者：
McCarthy, Mary K.;Morrison, Thomas E.
与持续性 RNA 病毒感染相关的慢性疾病是一个重要的公共卫生问题。虽然 1 型人类免疫缺陷病毒和丙型肝炎病毒可能是引起慢性疾病的持久性 RNA 病毒中最著名的例子，但有证据表明，许多其他 RNA 病毒，包括重新出现的病毒，如基孔肯雅病毒、埃博拉病毒和寨卡病毒，也会造成持续性感染。人们对 RNA 病毒导致慢性疾病的机制知之甚少。在这里，我们讨论病毒 RNA 的持续存在如何通过激活 RNA 传感途径来驱动慢性疾病的表现。
Chronic disease associated with persistent RNA virus infections represents a key public health concern. While human immunodeficiency virus-1 and hepatitis C virus are perhaps the most well-known examples of persistent RNA viruses that cause chronic disease, evidence suggests that many other RNA viruses, including re-emerging viruses such as chikungunya virus, Ebola virus and Zika virus, establish persistent infections. The mechanisms by which RNA viruses drive chronic disease are poorly understood. Here, we discuss how the persistence of viral RNA may drive chronic disease manifestations via the activation of RNA sensing pathways.