Calculation of the FDG lumped constant by simultaneous measurements of global glucose and FDG metabolism in humans
Calculation of the FDG lumped constant by simultaneous measurements of global glucose and FDG metabolism in humans
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DOI：
10.1097/00004647-199802000-00005
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发表时间：
1998-02-01
影响因子：
6.3
通讯作者：
Paulson, OB
中科院分区：
文献类型：
--
作者：
Hasselbalch, SG;Madsen, PL;Paulson, OB
集总常数定义为氟-2-脱氧-D-葡萄糖 (FDG) 和葡萄糖的净摄取量之间的换算系数，通过全局 CMRglc 和使用 FDG 作为示踪剂的正电子发射断层扫描 (PET) (CMRFDG) 进行计算。对 15 名健康正常志愿者（平均年龄 24 +/- 4 岁）进行了研究。使用 Xe-133 作为示踪剂，通过 Kety-Schmidt 技术测量整体 CBF 和 CMRglc，并对脑组织和脑静脉血之间惰性气体示踪剂的不完全扩散平衡造成的误差进行校正。 CMRFDG 的测量是通过 PET 使用动态和单扫描方法以及 K-1-k(3) 模型获得的。 Kety-Schmidt 技术和 PET-FDG 的测量同时进行。总CBF为47.1±8.0mL.100g(-1).min(-1)，CMRglc为22.8±4.1μmol.100g(-1).min(-1)。两种方法（动态和单次扫描方法分别为 17.8 +/- 1.6 和 18.2 +/- 1.3 mu mol.100 g(-1).min(-1)）没有发现 CMRFDG 差异。因此，集总常数的范围为 0.80 +/- 0.16 至 0.82 +/- 0.15，平均值为 0.81 +/- 0.15。 FDG 和葡萄糖磷酸化之间的平均比率 (k(3)*/k(3)) 为 0.39 +/- 0.15。本研究确定的集总常数与之前获得的值之间的差异可以部分地用方法学问题来解释，我们得出的结论是，大部分差异是由于之前对全局 CBF 的高估造成的。
The lumped constant defined as the conversion factor between the net uptake of fluoro-2-deoxy-D-glucose (FDG) and glucose was calculated from global CMRglc and from positron emission tomography (PET) using FDG as tracer (CMRFDG), Fifteen healthy, normal volunteers (mean age 24 +/- 4 years) were studied. Global CBF and CMRglc were measured with the Kety-Schmidt technique using Xe-133 as tracer, and values were corrected for errors from incomplete diffusion equilibrium for inert gas tracer between brain tissue and cerebral venous blood. Measurements of CMRFDG were obtained with PET using the dynamic and single-scan methods and the K-1-k(3) model. Measurements with the Kety-Schmidt technique and PET-FDG were performed simultaneously. Global CBF was 47.1 +/- 8.0 mL.100 g(-1).min(-1), and CMRglc was 22.8 +/- 4.1 mu mol.100 g(-1).min(-1). No difference in CMRFDG was found with the two methods (17.8 +/- 1.6 and 18.2 +/- 1.3 mu mol.100 g(-1).min(-1), dynamic and single scan methods, respectively). Accordingly, the lumped constant ranged from 0.80 +/- 0.16 to 0.82 +/- 0.15, with a mean value of 0.81 +/- 0.15. The mean ratio between phosphorylation of FDG and glucose (k(3)*/k(3)) was 0.39 +/- 0.15. The discrepancy between the lumped constant determined in this study and previously obtained values can be explained partly by methodologic problems, and we conclude that most of the discrepancy results from previous overestimation of global CBF.