From Molecular Fossils of Bacterial Hopanoids to the Formation of Isoprene Units: Discovery and Elucidation of the Methylerythritol Phosphate Pathway
From Molecular Fossils of Bacterial Hopanoids to the Formation of Isoprene Units: Discovery and Elucidation of the Methylerythritol Phosphate Pathway
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DOI：
10.1007/s11745-008-3261-7
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发表时间：
2008-12-01
期刊：
影响因子：
1.9
通讯作者：
Rohmer, Michel
中科院分区：
文献类型：
--
作者：
Rohmer, Michel
对细菌三萜类化合物的生物合成的调查导致意外地发现了一个替代的甲羟戊酸独立途径形成异戊二烯单元。已经呈现C-5支化异戊二烯骨架的甲基异戊二醇磷酸酯是关键中间体。这一途径的特点是独立的银杏胚形成的二萜类化合物。它存在于大多数细菌和属于光养门的所有生物体的质体中。本文综述了发现和阐明这一代谢途径的关键步骤。
Investigations on the biosynthesis of bacterial triterpenoids of the hopane series led to the unexpected discovery of an alternative mevalonate independent pathway for the formation of isoprene units. Methylerythritol phosphate, already presenting the C-5 branched isoprene skeleton, is the key intermediate. This pathway was independently characterized in ginkgo embryos for the formation of diterpenoids. It is present in most bacteria and in the plastids of all organisms belonging to phototrophic phyla. The key steps of the discovery and elucidation of this metabolic route are presented in this review.