Research priorities for global measles and rubella control and eradication
Research priorities for global measles and rubella control and eradication
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DOI：
10.1016/j.vaccine.2012.04.058
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发表时间：
2012-07-06
期刊：
影响因子：
5.5
通讯作者：
Strebel, Peter M.
中科院分区：
文献类型：
--
作者：
Goodson, James L.;Chu, Susan Y.;Strebel, Peter M.
2010年，世界卫生组织召集的一个专家咨询小组对消除麻疹的可行性进行了评估，得出以下结论：（1）麻疹能够且应该被消除；（2）如果在实现现有的2015年麻疹死亡率降低目标方面取得可衡量的进展，那么到2020年消除麻疹是可行的；（3）消除麻疹的活动应在加强常规免疫服务的背景下开展；（4）消除麻疹的活动应用于加速风疹和先天性风疹综合征（CRS）的控制和消除。专家咨询小组还强调了研究和创新在任何疾病控制或消除计划中的关键作用。2011年5月，召开了一次会议，以确定研究重点并对其进行优先排序，从而为麻疹和风疹/CRS的控制以及潜在的消除活动提供支持。本综述介绍了会议参与者确定的问题以及它们在以下类别中的相对优先级：（1）麻疹流行病学；（2）疫苗研发和替代疫苗接种方式；（3）监测和实验室方法；（4）免疫策略；（5）数学建模和经济分析；（6）风疹/CRS的控制和消除。
In 2010, an expert advisory panel convened by the World Health Organization to assess the feasibility of measles eradication concluded that (1) measles can and should be eradicated, (2) eradication by 2020 is feasible if measurable progress is made toward existing 2015 measles mortality reduction targets, (3) measles eradication activities should occur in the context of strengthening routine immunization services, and (4) measles eradication activities should be used to accelerate control and elimination of rubella and congenital rubella syndrome (CRS). The expert advisory panel also emphasized the critical role of research and innovation in any disease control or eradication program. In May 2011, a meeting was held to identify and prioritize research priorities to support measles and rubella/CRS control and potential eradication activities. This summary presents the questions identified by the meeting participants and their relative priority within the following categories: (1) measles epidemiology, (2) vaccine development and alternative vaccine delivery, (3) surveillance and laboratory methods, (4) immunization strategies, (5) mathematical modeling and economic analyses, and (6) rubella/CRS control and elimination.