Structural characterization of calcium alginate matrices by means of mechanical and release tests.
Structural characterization of calcium alginate matrices by means of mechanical and release tests.
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DOI：
10.3390/molecules14083003
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发表时间：
2009-08-12
期刊：
影响因子：
--
通讯作者：
Grassi G
中科院分区：
文献类型：
--
作者：
Grassi M;Sandolo C;Perin D;Coviello T;Lapasin R;Grassi G
本文采用力学方法对模型药物(肌红蛋白)负载的海藻酸钙水凝胶进行了表征，并进行了海藻酸钙水凝胶中肌红蛋白的释放实验。在固定温度下，对不同聚合物浓度组成的基质进行了松弛试验(力学研究)。用广义Maxwell模型对不同基质的松弛行为进行了解释；研究结果表明，当聚合物浓度大于0.5g/100mL时，基质表现为固体材料。此外，还观察到基质的力学性能随聚合物浓度的增加而增加。关于释放试验，测定了肌红蛋白在基质中的扩散系数与聚合物浓度的关系。然后分别用弗洛里理论和修正的自由体积理论分析力学数据和释放数据，以估计网络网格大小ξ。两种方法得到的筛分尺寸之间的比较表明，对于大于0.5g/100毫升的聚合物浓度，两者是令人满意的一致。应该注意的是，这里提出的确定聚合物网络网目的方法是绝对通用的，并且可以有利地应用于其他类似聚合物体系的表征。
In this paper we have concentrated on the characterization of calcium alginate hydrogels loaded with a model drug (myoglobin) by means of a mechanical approach; in addition, release tests of myoglobin from alginate hydrogels were performed. At a fixed temperature, relaxation tests (mechanical study) were carried out on matrices constituted by different polymer concentrations. The interpretation of the relaxation behavior of the different matrices was conducted using the generalized Maxwell model; as a result of this investigation it was possible to conclude that for polymer concentrations greater than 0.5 g/ 100 mL the matrices behaved as solid materials. In addition, it was observed that the mechanical properties of the matrices increased with polymer concentration. With regard to the release tests, the diffusion coefficient of myoglobin in the matrix in relation to polymer concentrations was determined. The mechanical and release data where then analyzed by Flory’s theory and by a modified free-volume theory, respectively, to estimate the network mesh size ξ. The comparison between the mesh sizes obtained by the two approaches showed a satisfactory agreement for polymer concentrations greater than 0.5 g/100 mL. It should be noted that the approach proposed here to determine the polymeric network meshes is absolutely general and can be advantageously applied to the characterization of other similar polymeric systems.
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影响因子：
11.2
作者：
SKJAKBRAEK, G;GRASDALEN, H;SMIDSROD, O
通讯作者：
SMIDSROD, O
影响因子：
4.9
作者：
Pasut, E.;Toffanin, R.;Grassi, M.
通讯作者：
Grassi, M.
DOI：
10.1139/v66-147
发表时间：
1966-01-01
期刊：
CANADIAN JOURNAL OF CHEMISTRY-BACK YEAR
影响因子：
--
作者：
GORIN, PAJ;SPENCER, JFT
通讯作者：
SPENCER, JFT
影响因子：
3.7
作者：
DUDA, JL;VRENTAS, JS;LIU, HT
通讯作者：
LIU, HT
影响因子：
5.5
作者：
Shellhammer, TH;Rumsey, TR;Krochta, JM
通讯作者：
Krochta, JM