Chromosomal organization of the inducible and constitutive prostaglandin synthase/cyclooxygenase genes in mouse.
Chromosomal organization of the inducible and constitutive prostaglandin synthase/cyclooxygenase genes in mouse.
复制标题
小鼠诱导型和组成型前列腺素合酶/环氧合酶基因的染色体组织。
DOI：
10.1006/geno.1993.1091
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发表时间：
1993
期刊：
影响因子：
4.4
通讯作者：
Lusis,AJ
中科院分区：
文献类型：
--
作者：
Wen,PZ;Warden,C;Fletcher,BS;Kujubu,DA;Herschman,HR;Lusis,AJ
两种不同的前列腺素合酶/环氧合酶（PGS/COS）酶最近已被确认。一种（EC 1.14.00.1）主要是组成型的，并且已经在多种物种中表征，而另一种（也称为TIS 10）是由有丝分裂原诱导的，并且可由糖皮质激素诱导。沿着磷脂酶A2的活化，后者PGS/COS可能介导多种细胞类型中配体诱导的前列腺素产生。这两种酶具有相似的基因结构和活性。越来越多的证据表明，PGS/考克斯活性可能在炎症性疾病中发挥作用。例如，PGS/考克斯表达在炎性关节疾病中上调，并且受遗传控制。作为研究调节PGS/考克斯表达的遗传因素和炎症性疾病小鼠模型中酶可能参与的努力的一部分，我们在这里报告了组成性和调节性PGS/考克斯酶基因的染色体定位。我们将组成型酶称为Pgs-1，诱导型酶称为Pgs-2。参考文献14篇，1个选项卡。
Two distinct prostaglandin synthase/cyclooxygenase (PGS/COS) enzymes have recently been recognized. One (EC 1.14.00.1) is largely constitutive and has been characterized in a variety of species, whereas the other (also known as TIS10) is inducible by mitogens and inhibitable by glucocorticoids. Along with activation of phospholipase A2, the latter PGS/COS is likely to mediate ligand-induced prostaglandin production in a variety of cell types. The two enzymes have similar gene structures and activities. There is accumulating evidence that PGS/COX activity may play a role in inflammatory diseases. For example, PGS/COX expression is upregulated in inflammatory joint diseases and is genetically controlled. As part of an effort to examine genetic factors regulating PGS/COX expression and the possible involvement of the enzymes in mouse models of inflammatory disorders, we report here the chromosomal mapping of the genes for the constitutive and regulated PGS/COX enzymes. We will refer to the constitutive enzyme as Pgs-1 and the inducible enzyme as Pgs-2. 14 refs., 1 tab.