Systemic infections mimicking thrombotic thrombocytopenic purpura
Systemic infections mimicking thrombotic thrombocytopenic purpura
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DOI：
10.1002/ajh.22091
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发表时间：
2011-09-01
影响因子：
12.8
通讯作者：
George, James N.
中科院分区：
文献类型：
--
作者：
Booth, Kristina K.;Terrell, Deirdra R.;George, James N.
缺乏特定的诊断标准，开始血浆交换治疗的紧迫性以及血浆交换并发症的风险使得对疑似血栓性血小板减少性紫癜（TTP）患者进行初步评估。全身感染可能模仿TTP的临床特征。在俄克拉荷马州TTP-HUS（溶血性尿毒症综合征）注册中心，1989 - 2010年，有415例连续的患者被临床诊断为TTP的第一集。在31（7％）中，呈现临床特征随后归因于全身感染。所有31名患者均均具有TTP的诊断标准； 16（52％）的微型溶血性贫血，血小板减少症，神经系统异常，肾衰竭和发烧的完全“五角”。 25例ADAMTS13测量的患者中有4名（16％）的患者具有
The absence of specific diagnostic criteria, the urgency to begin plasma exchange treatment, and the risk for complications from plasma exchange make the initial evaluation of patients with suspected thrombotic thrombocytopenic purpura (TTP) difficult. Systemic infections may mimic the presenting clinical features of TTP. In the Oklahoma TTP-HUS (hemolytic-uremic syndrome) Registry, 1989-2010, 415 consecutive patients have been clinically diagnosed with their first episode of TTP; in 31 (7%) the presenting clinical features were subsequently attributed to a systemic infection. All 31 patients had diagnostic criteria for TTP; 16 (52%) had the complete "pentad" of microangiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities, renal failure, and fever. Four (16%) of 25 patients who had ADAMTS13 measurements had