Migraine and MTHFR C677T genotype in a population-based sample
Migraine and MTHFR C677T genotype in a population-based sample
复制标题
DOI：
10.1002/ana.20755
复制
发表时间：
2006-02-01
影响因子：
11.2
通讯作者：
Launer, LJ
中科院分区：
文献类型：
--
作者：
Scher, AI;Terwindt, GM;Launer, LJ
目的：先兆偏头痛与卒中风险增加相关。MTHFR C677 T基因型与选定的临床样本中偏头痛风险增加以及高同型半胱氨酸（中风的危险因素）相关。我们评估了MTHFR C677 T变异与偏头痛的关系，以及心血管危险因素和基因型状态代谢标志物的介导作用。（MA; n = 187），无先兆（MO; n = 226）和非偏头痛患者（n = 1，212）来自偏头痛人群遗传流行病学研究。与野生型基因型相比，T/T基因型与MA的几率增加相关（比值比[OR]，2.05; 95%置信区间，1.2-3.4; p < 0.006），T等位基因数量有增加的趋势（OR，1.40; 95%置信区间，1.1-1.8; p < 0.007）。调整同型半胱氨酸后，OR略有减弱。解释：MA的风险与MTHFR C674 T纯合性相关，独立于其他心血管危险因素。
Objective: Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status.Methods: We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study.Results: Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine.Interpretation: Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.