Biocompatibility and osseointegration of nanostructured titanium dental implants in minipigs
Biocompatibility and osseointegration of nanostructured titanium dental implants in minipigs
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DOI：
10.1111/clr.13589
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发表时间：
2020-02-28
影响因子：
4.3
通讯作者：
Layrolle, Pierre
中科院分区：
文献类型：
--
作者：
Hoornaert, Alain;Vidal, Luciano;Layrolle, Pierre
目的牙种植体的表面处理对种植体的骨结合率有很大的影响。本研究的目的是比较生物相容性和骨种植体接触（BIC）的钛牙科种植体与不同的表面treatments.Material和方法测试植入物（Biotech牙科）有一个纳米结构的表面和控制植入物（Anthogyr）喷砂与双相磷酸钙和酸蚀刻的表面。将两种钛种植体植入6头尤卡坦小型猪的下颌骨和上颌骨中4周和12周（n = 10个种植体/组）。非脱钙组织学和背散射电子显微镜images.Results的阅读的组织学切片由一个antomo病理学家的生物相容性和骨整合进行了评价表明，测试植入物被认为是非刺激性的周围组织，因此与对照植入物生物相容性。BIC值均高于测试比对照牙种植体在4和12 weeks.Conclusions，新的纳米结构钛牙种植体被认为是生物相容性，并表现出更好的骨整合比对照种植体在4和12周。
Objectives It is well known that surface treatments of dental implants have a great impact on their rate of osseointegration. The aim of this study was to compare the biocompatibility and the bone-implant contact (BIC) of titanium dental implants with different surface treatments.Material and methods Test implants (Biotech Dental) had a nanostructured surface and control implants (Anthogyr) were grit-blasted with biphasic calcium phosphate and acid-etched surface. Both titanium implants were inserted in mandible and maxillary bones of 6 Yucatan minipigs for 4 and 12 weeks (n = 10 implants/group). Biocompatibility and osseointegration were evaluated by non-decalcified histology and back-scattered electron microscopy images.Results The reading of histology sections by an antomo-pathologist indicated that the test implants were considered non-irritating to the surrounding tissues and thus biocompatible compared with control implants. The BIC values were higher for test than for control dental implants at both 4 and 12 weeks.Conclusions In summary, the new nanostructured titanium dental implant is considered biocompatible and showed a better osseointegration than the control implant at both 4 and 12 weeks.