The epigenetic landscape in the course of time: Conrad Hal Waddington's methodological impact on the life sciences
The epigenetic landscape in the course of time: Conrad Hal Waddington's methodological impact on the life sciences
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DOI：
10.1016/j.shpsc.2013.06.001
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发表时间：
2013-12-01
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影响因子：
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通讯作者：
Baedke, Jan
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文献类型：
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作者：
Baedke, Jan
康拉德·哈尔·沃丁顿的工作似乎从未真正在主流生物学中获得过认可。本文，提供了一个跨学科的调查方法，使用他的表观遗传景观图像，认为（i）沃丁顿的遗产是更广泛的比通常认识到，它是广泛的生命科学（如干细胞生物学，发展心理学和文化人类学）。此外，我将表明，（ii）存在尚未认识到的启发式作用，特别是在模型的建设和理论的形成，其中沃丁顿的图像在他的工作中发挥。沃丁顿设想的这些不同的方法论方面被用来作为一个自然的框架，分析和分类的方式使用后沃丁顿的“景观方法”的后生景观图像。对沃丁顿图像遗产的评估表明，生命科学领域存在高度多样化的传统，这些传统深深植根于沃丁顿的方法论工作中。(C)2013爱思唯尔有限公司版权所有。
It seems that the reception of Conrad Hal Waddington's work never really gathered speed in mainstream biology. This paper, offering a transdisciplinary survey of approaches using his epigenetic landscape images, argues that (i) Waddington's legacy is much broader than is usually recognized-it is widespread across the life sciences (e.g. stem cell biology, developmental psychology and cultural anthropology). In addition, I will show that (ii) there exist as yet unrecognized heuristic roles, especially in model building and theory formation, which Waddington's images play within his work. These different methodological facets envisioned by Waddington are used as a natural framework to analyze and classify the manners of usage of epigenetic landscape images in post-Waddingtonian 'landscape approaches'. This evaluation of Waddington's pictorial legacy reveals that there are highly diverse lines of traditions in the life sciences, which are deeply rooted in Waddington's methodological work. (C) 2013 Elsevier Ltd. All rights reserved.