Evidence of Local HIV Transmission in the African Community of King County, Washington
Evidence of Local HIV Transmission in the African Community of King County, Washington
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DOI：
10.1007/s10903-016-0458-3
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发表时间：
2017-08-01
影响因子：
1.9
通讯作者：
Golden, Matthew R.
中科院分区：
文献类型：
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作者：
Kerani, Roxanne P.;Herbeck, Joshua T.;Golden, Matthew R.
关于美国非洲移民社区内艾滋病毒持续传播的频率知之甚少。我们使用艾滋病毒监测和合作伙伴服务数据来描述2010年1月1日至2013年12月31日华盛顿州金县（KC）新报告的非洲出生的艾滋病毒感染者。我们对HIV-1 pol进行系统发育聚类分析，以确定该人群中假定的传播事件。从2010年到2013年，1148名KC成年人被报告感染艾滋病毒，其中102人（9%）出生在非洲。41例非洲出生的病例在抵达美国后接受了采访并报告了诊断。14例（34%）在诊断前报告了ae 1阴性检测，9例（26%）在抵达美国后报告了ae 1阴性检测。Pol基因型可用于这九个中的七个。在这7个病例中，有2个病例的亲缘关系最近，另外2个感染了B亚型病毒。我们发现大量证据表明，艾滋病毒正在KC的非洲社区传播。
Little is known about the frequency of ongoing HIV transmission within U.S. African immigrant communities. We used HIV surveillance and partner services data to describe African-born persons newly reported with HIV infection in King County (KC), WA from 1/1/2010 to 12/31/2013. We performed phylogenetic clustering analysis of HIV-1 pol to identify putative transmission events within this population. From 2010 to 2013, 1148 KC adults were reported with HIV, including 102 (9 %) born in Africa. Forty-one African-born cases were interviewed and reported diagnosis after arrival in the U.S. Fourteen (34 %) reported ae1 negative test prior to diagnosis, and 9 (26 %) reported ae1 negative test after U.S. arrival. Pol genotypes were available for seven of these nine. For two of these seven, a KC case was the nearest phylogenetic neighbor; two others were infected with subtype B virus. We found substantial evidence of ongoing HIV transmission in the African community of KC.