Goal- and retrieval-dependent activity in the striatum during memory recognition
Goal- and retrieval-dependent activity in the striatum during memory recognition
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DOI：
10.1016/j.neuropsychologia.2015.04.011
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发表时间：
2015-06-01
期刊：
影响因子：
2.6
通讯作者：
Sommer, Tobias
中科院分区：
文献类型：
--
作者：
Clos, Mareike;Schwarze, Ulrike;Sommer, Tobias
纹状体与成功的记忆提取有关，但确切的功能联系仍然不清楚。一种假设是，纹状体活动反映了依赖于当前行为目标的检索结果的主动评估过程，而不是记忆重新激活的结果。我们最近发现，纹状体也与记忆识别的信心相关，这可能反映了高确定性决策的高主观价值。为了检验记忆再认过程中纹状体的活动是否确实反映了主观价值，我们使用再认记忆范式进行了一项fMRI研究，在该研究中，参与者不仅对再认信心进行了评级，而且还指出了与先前记忆提取相关的愉快程度。结果表明，在行为和大脑激活水平上，特别是在纹状体中，自信和愉快之间存在高度正相关。由于纹状体置信度信号中几乎所有的方差都可以用经历过的愉快来解释，因此纹状体记忆识别反应的这一部分可能对应于高置信度反应的更大主观值。虽然感知老年也与纹状体活动密切相关，这种激活模式是明显不同的与信心和愉快，因此不能解释较高的主观价值，以检测“老”的项目。总之，这些结果表明，至少有两个独立的过程有助于纹状体激活识别记忆：一个更灵活的评价反应依赖于上下文和目标所捕获的记忆信心和潜在的检索相关的反应所捕获的感知老年。(C)2015爱思唯尔有限公司版权所有。
The striatum has been associated with successful memory retrieval but the precise functional link still remains unclear. One hypothesis is that striatal activity reflects an active evaluation process of the retrieval outcome dependent on the current behavioral goals rather than being a consequence of memory reactivation. We have recently shown that the striatum also correlates with confidence in memory recognition, which could reflect high subjective value ascribed to high certainty decisions. To examine whether striatal activity during memory recognition reflects subjective value indeed, we conducted an fMRI study using a recognition memory paradigm in which the participants rated not only the recognition confidence but also indicated the pleasantness associated with the previous memory retrieval. The results demonstrated a high positive correlation between confidence and pleasantness both on the behavioral and brain activation level particularly in the striatum. As almost all of variance in the striatal confidence signal could be explained by experienced pleasantness, this part of the striatal memory recognition response probably corresponds to greater subjective value of high confidence responses. While perceived oldness was also strongly correlated with striatal activity, this activation pattern was clearly distinct from that associated with confidence and pleasantness and thus could not be explained by higher subjective value to detect "old" items. Together, these results show that at least two independent processes contribute to striatal activation in recognition memory: a more flexible evaluation response dependent on context and goals captured by memory confidence and a potentially retrieval-related response captured by perceived oldness. (C) 2015 Elsevier Ltd. All rights reserved.