In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja.
In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja.
复制标题
isosungucine（一种来自马钱子的吲哚单萜生物碱）的体内抗疟活性。
作者：
Geneviève Philippe;L. Nguyen;L. Angenot;M. Frédérich;G. Moonen;M. Tits;J. Rigo
异松萝碱（1）是从马钱子（Strychnos icaja）的根中分离得到的准对称双吲哚单萜生物碱。测定了针对P. vinckei petteri鼠菌株的体内抗疟活性。在Peters的4天抑制试验中，1在第4天以30 mg/kg的剂量通过腹膜内途径抑制寄生虫血症几乎50%。
Isosungucine (1) is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of Strychnos icaja. The in vivo antimalarial activity against the P. vinckei petteri murine strain was determined. In the Peters 4-day suppressive test, 1 suppressed the parasitemia by almost 50 percent on day 4 at the dose of 30 mg/kg by intraperitoneal route.