Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study
Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study
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DOI：
10.1530/eje-07-0250
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发表时间：
2007-10-01
影响因子：
5.8
通讯作者：
Kiess, Wieland
中科院分区：
文献类型：
--
作者：
Galler, Angela;Gelbrich, Goetz;Kiess, Wieland
目的：脂联素在肥胖、2型糖尿病和心血管疾病的病理生理中起重要作用。本研究的目的是以纵向方式测定儿童和青少年I型糖尿病患者的脂联素浓度，并研究年龄、性别的影响。研究设计和方法：在这项研究中，88名1型糖尿病儿童和青少年。对糖尿病患者进行纵向随访。在基线和随访期间，通过酶联免疫法测定血清脂联素水平，并与临床数据、HbA 1c和血脂相关。结果：1型糖尿病患儿血清脂联素水平明显高于正常对照组（P < 0.05）。糖尿病儿童与健康儿童相比（基线时13.1 vs 9.1 μ g/ml，P < 0.001）。脂联素浓度与BMI s.d.s呈负相关（P < 0.001）。脂联素水平在性别、糖尿病病程或HbA 1c方面无显著差异。男性I型糖尿病患者青春期脂联素水平下降（P = 0.03），而女性则无明显变化。在新发1型糖尿病患者的亚组中。糖尿病脂联素浓度与对照组无差异，但在随访期间升高（P = 0.007）。多元逐步回归分析显示，1型糖尿病患者脂联素水平的最重要预测因素。结果：1型糖尿病儿童和青少年血清脂联素水平较健康儿童明显升高（β = 0.574，P < 0.001），BMI标准差（0 =-0.302，p = 0.001，r（2）= 0.56）。
Objective: Adiponectin plays an important role in pathophysiology of obesity, type 2 diabetes and cardiovascular disease. The aim of this study was to determine adiponectin concentrations in children and adolescents with type I diabetes in a longitudinal manner and to study the impact of age, gender. body mass index (BMI) and metabolic control.Research design and methods: In this study, 88 children and adolescents with type 1. diabetes were followed longitudinally. At baseline and during follow-up, serum levels of adiponectin were measured by enzyme-linked immunoassay and correlated with clinical data, HbA1c and lipids. Healthy children (n = 259) were chosen as a control group.Results: Serum adiponectin levels were significantly higher in children with type 1. diabetes compared with healthy children (13.1 vs 9.1 mu g/ml at baseline, P < 0.001). Adiponectin concentrations inversely correlated with BMI s.d.s (P < 0.001). No significant difference of adiponectin levels regarding gender, diabetes duration or HbA1c was seen. Adiponectin concentrations decreased in males with type I diabetes during puberty (P = 0.03) while there was no significant change in females. in a subgroup of patients with new onset type 1. diabetes. adiponectin concentrations were not different from adiponectin levels in control subjects but increased during follow-up (P = 0.007). Stepwise multiple regression analysis showed that most important predictors of adiponectin levels in type 1. diabetes at the end of the study were adiponectin concentration at baseline ( beta = 0.574, P < 0.001) and BMI s.d.s (0 = -0.302, p = 0.001, r(2) = 0.56).Conclusions: Children and adolescents with type 1 diabetes have BMI-dependent elevated serum concentrations of adiponectin compared with healthy children.